In vitro and in vivo antioxidant potentials of the methanolic crude extract from Inula glomerata Oliv. & Hiern (Asteraceae) and Salacia kraussii (Harv.) Harv (Celastraceae)

dc.contributor.authorOjo, Michael C.
dc.contributor.authorOsunsanmi, Foluso Oluwagbemiga
dc.contributor.authorCele, Nkosinathi D.
dc.contributor.authorZharare, Godfrey E.
dc.contributor.authorMosa, Rebamang Anthony
dc.contributor.authorOpoku, Andy R.
dc.date.accessioned2021-09-08T11:31:04Z
dc.date.available2021-09-08T11:31:04Z
dc.date.issued2021-07
dc.description.abstractReactive oxygen species are implicated in multiple pathological conditions including erectile dysfunction. This study evaluated the in vitro and in vivo antioxidant potential of the methanolic extracts of Inula glomerata and Salacia kraussii. The plant materials were pulverized and extracted with methanol. The phytochemical analysis, ability of the crude extracts to scavenge free radicals (ABTS, DPPH, NO.) in vitro as well as the total phenolic and flavonoid contents was investigated. In vivo, antioxidant potentials of the crude extracts (50/250 mg/kg body weight) were determined in an erectile dysfunction rat model. The phytochemical analysis revealed that both plants contain flavonoids, tannins, terpenoids, and alkaloids. The crude extracts at varying degree of efficiency, scavenged ABTS and DPPH radicals. The crude extracts at low concentrations (50 mg/kg b.w) significantly (p<0.05) diminished the level of malondialdehyde, augmented catalase activities and elevated glutathione levels. However, SOD activities were significantly boosted in a dose-dependent manner by the crude extracts. Therefore, I. glomerata and S. kraussii possess antioxidant properties, hence, can serve as a therapeutic modality in the treatment of oxidative stress-induced erectile dysfunction.en_ZA
dc.description.departmentBiochemistryen_ZA
dc.description.departmentGeneticsen_ZA
dc.description.departmentMicrobiology and Plant Pathologyen_ZA
dc.description.librarianpm2021en_ZA
dc.description.urihttps://blacpma.ms-editions.cl/index.php/blacpmaen_ZA
dc.identifier.citationOjo MC, Osunsanmi FO, Cele ND, Zharare GE, Mosa RA, Opoku AR. In vitro and in vivo antioxidant potentials of the methanolic crude extract from Inula glomerata Oliv. & Hiern (Asteraceae) and Salacia kraussii (Harv.) Harv (Celastraceae). Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticastas 20 (4): 416 - 426 (2021). https://doi.org/10.37360/blacpma.21.20.4.31.en_ZA
dc.identifier.issn0717-7917 (online)
dc.identifier.other10.37360/blacpma.21.20.4.31
dc.identifier.urihttp://hdl.handle.net/2263/81733
dc.language.isoenen_ZA
dc.publisherMS-Editionsen_ZA
dc.rights© ISSN 0717 7917 / www.blacpma.ms-editions.clen_ZA
dc.subjectAntioxidantsen_ZA
dc.subjectFree radicalsen_ZA
dc.subjectReactive oxygen speciesen_ZA
dc.subjectOxidative stressen_ZA
dc.subjectInula glomerataen_ZA
dc.subjectSalacia krausiien_ZA
dc.titleIn vitro and in vivo antioxidant potentials of the methanolic crude extract from Inula glomerata Oliv. & Hiern (Asteraceae) and Salacia kraussii (Harv.) Harv (Celastraceae)en_ZA
dc.typeArticleen_ZA

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Ojo_InVitro_2021.pdf
Size:
690.58 KB
Format:
Adobe Portable Document Format
Description:
Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description: