Navigating the transcriptional roadmap regulating plant secondary cell wall deposition

dc.contributor.authorHussey, Steven Grant
dc.contributor.authorMizrachi, Eshchar
dc.contributor.authorCreux, Nicole Marie
dc.contributor.authorMyburg, Alexander Andrew
dc.contributor.emailzander.myburg@up.ac.zaen_US
dc.date.accessioned2013-11-25T07:34:20Z
dc.date.available2013-11-25T07:34:20Z
dc.date.issued2013-08-29
dc.description.abstractThe current status of lignocellulosic biomass as an invaluable resource in industry, agriculture, and health has spurred increased interest in understanding the transcriptional regulation of secondary cell wall (SCW) biosynthesis. The last decade of research has revealed an extensive network of NAC, MYB and other families of transcription factors regulating Arabidopsis SCW biosynthesis, and numerous studies have explored SCW-related transcription factors in other dicots and monocots. Whilst the general structure of the Arabidopsis network has been a topic of several reviews, they have not comprehensively represented the detailed protein-DNA and protein-protein interactions described in the literature, and an understanding of network dynamics and functionality has not yet been achieved for SCW formation. Furthermore the methodologies employed in studies of SCW transcriptional regulation have not received much attention, especially in the case of non-model organisms. In this review, we have reconstructed the most exhaustive literature-based network representations to date of SCW transcriptional regulation in Arabidopsis. We include a manipulable Cytoscape representation of the Arabidopsis SCW transcriptional network to aid in future studies, along with a list of supporting literature for each documented interaction. Amongst other topics, we discuss the various components of the network, its evolutionary conservation in plants, putative modules and dynamic mechanisms that may influence network function, and the approaches that have been employed in network inference. Future research should aim to better understand network function and its response to dynamic perturbations, whilst the development and application of genome-wide approaches such as ChIP-seq and systems genetics are in progress for the study of SCW transcriptional regulation in non-model organisms.en_US
dc.description.librarianam2013en_US
dc.description.sponsorshipThe Mandela Rhodes Foundation and National Research Foundation of South Africaen_US
dc.description.urihttp://www.frontiersin.orgen_US
dc.identifier.citationHussey, SG, Mizrachi, E, Creux, NM & Myburg, AA 2013, 'Navigating the transcriptional roadmap regulating plant secondary cell wall deposition', Frontiers in Plant Science, vol. 4, no. 325, pp. 1-22.en_US
dc.identifier.issn1664-462X (online)
dc.identifier.other10.3389/fpls.2013.00325
dc.identifier.urihttp://hdl.handle.net/2263/32589
dc.language.isoenen_US
dc.rights© 2013 Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectTranscriptional networken_US
dc.subjectTranscription factoren_US
dc.subjectArabidopsisen_US
dc.subjectWood formationen_US
dc.subjectSecondary cell wall (SCW)en_US
dc.titleNavigating the transcriptional roadmap regulating plant secondary cell wall depositionen_US
dc.typeArticleen_US

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