Investigation of biological samples for monofluoroacetate and Dichapetalum cymosum poisoning in southern Africa
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Date
Authors
Minnaar, P.P.
McCrindle, Robert Ian
Naude, T.W.
Botha, C.J. (Christoffel Jacobus)
Journal Title
Journal ISSN
Volume Title
Publisher
Published by the Agricultural Research Council, Onderstepoort Veterinary Institute .
Abstract
A need has existed for the accurate identification of monofluoroacetate (MFA) poisoning in southern Africa. The development of a new method for the determination of MFA has made the analysis of a variety of biological samples (n=50) feasible. The method has been used in the laboratory over 24 months. Monofluoroacetate was present in 66% of samples from cases of suspected poisoning, reflecting the extent of the problem. Stability of MFA in samples was also determined so as to have a time-bound baseline for the acceptance of samples submitted. It was found that there was a decrease in the level of MFA and, after 14 days at room temperature, only 50% of the spiked dose could be identified. It is suggested that samples be analyzed within 7 days of mortality if they not kept frozen.
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Keywords
Veterinary medicine, Dichapetalum cymosum, Gifblaar, Liquid chromatography, Monofluoroacetate poisoning
Sustainable Development Goals
Citation
Minnaar, PP, McCrindle, RI, Naude, TW & Botha, CJ 2000, 'Investigation of biological samples for monofluoroacetate and Dichapetalum cymosum poisoning in southern Africa’. Onderstepoort Journal of Veterinary Research, vol. 67, no. 1, pp. 27-30.