Best practice in the chemical characterisation of extracts used in pharmacological and toxicological researcht - the ConPhyMP-guidelines

dc.contributor.authorHeinrich, Michael
dc.contributor.authorJalil, Banaz
dc.contributor.authorAbdel-Tawab, Mona
dc.contributor.authorEcheverria, Javier
dc.contributor.authorKulić, Zarko
dc.contributor.authorMcGaw, Lyndy Joy
dc.contributor.authorPezzuto, John M.
dc.contributor.authorPotterat, Olivier
dc.contributor.authorWang, Jia-Bo
dc.date.accessioned2022-11-01T09:25:44Z
dc.date.available2022-11-01T09:25:44Z
dc.date.issued2022-09-13
dc.description.abstractBACKGROUND : Research on medicinal plants and extracts derived from them differs from studies performed with single compounds. Extracts obtained from plants, algae, fungi, lichens or animals pose some unique challenges: they are multicomponent mixtures of active, partially active and inactive substances, and the activity is often not exerted on a single target. Their composition varies depending on the method of preparation and the plant materials used. This complexity and variability impact the reproducibility and interpretation of pharmacological, toxicological and clinical research. OBJECTIVES : This project develops best practice guidelines to ensure reproducibility and accurate interpretations of studies using medicinal plant extracts. The focus is on herbal extracts used in pharmacological, toxicological, and clinical/intervention research. Specifically, the consensus-based statement focuses on defining requirements for: 1) Describing the plant material/herbal substances, herbal extracts and herbal medicinal products used in these studies, and 2) Conducting and reporting the phytochemical analysis of the plant extracts used in these studies in a reproducible and transparent way. THE PROCESS AND METHODS : We developed the guidelines through the following process: 1) The distinction between the three main types of extracts (extract types A, B, and C), initially conceptualised by the lead author (MH), led the development of the project as such; 2) A survey among researchers of medicinal plants to gather global perspectives, opportunities, and overarching challenges faced in characterising medicinal plant extracts under different laboratory infrastructures. The survey responses were central to developing the guidelines and were reviewed by the core group; 3) A core group of 9 experts met monthly to develop the guidelines through a Delphi process; and. 4) The final draft guidelines, endorsed by the core group, were also distributed for feedback and approval to an extended advisory group of 20 experts, including many journal editors. OUTCOME : The primary outcome is the “Consensus statement on the Phytochemical Characterisation of Medicinal Plant extracts“ (ConPhyMP) which defines the best practice for reporting the starting plant materials and the chemical methods recommended for defining the chemical compositions of the plant extracts used in such studies. The checklist is intended to be an orientation for authors in medicinal plant research as well as peer reviewers and editors assessing such research for publication.en_US
dc.description.departmentParaclinical Sciencesen_US
dc.description.librariandm2022en_US
dc.description.sponsorshipWillmar Schwabe GmbH & Co. KG, Germany.en_US
dc.description.urihttps://www.frontiersin.org/journals/pharmacologyen_US
dc.identifier.citationHeinrich, M., Jalil, B., Abdel-Tawab, M., Echeverria, J., Kulic, A., McGaw, L.J., Pezzuto, J.M., Potterat, O., Wang, J.B. (2022), Best Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelines. Frontiers in Pharmacology 13:953205. doi: 10.3389/fphar.2022.953205.en_US
dc.identifier.issn1663-9812 (online)
dc.identifier.other10.3389/fphar.2022.953205
dc.identifier.urihttps://repository.up.ac.za/handle/2263/88046
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.rights© 2022 Heinrich, Jalil, Abdel-Tawab, Echeverria, Kulić, McGaw, Pezzuto, Potterat and Wang. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY).en_US
dc.subjectBest practiceen_US
dc.subjectExtract characterisationen_US
dc.subjectMedicinal planten_US
dc.subjectAnalytical methodsen_US
dc.subjectPhytochemical analysisen_US
dc.subjectHPLCen_US
dc.subjectHigh-performance thin-layer chromatography (HPTLC)en_US
dc.subjectHigh performance liquid chromatography (HPLC)en_US
dc.titleBest practice in the chemical characterisation of extracts used in pharmacological and toxicological researcht - the ConPhyMP-guidelinesen_US
dc.typeArticleen_US

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