Development and prospects of dedicated tracers for the molecular imaging of bacterial infections

dc.contributor.authorBunschoten, Anton
dc.contributor.authorWelling, M.M.
dc.contributor.authorTermaat, M.F.
dc.contributor.authorSathekge, Mike Machaba
dc.contributor.authorVan Leeuwen, F.W.B.
dc.date.accessioned2014-06-06T10:59:06Z
dc.date.available2014-06-06T10:59:06Z
dc.date.issued2013-12
dc.description.abstractBacterial infections have always been, and still are, a major global healthcare problem. For accurate treatment it is of utmost importance that the location(s), severity, type of bacteria, and therapeutic response can be accurately staged. Similar to the recent successes in oncology, tracers specific for molecular imaging of the disease may help advance the patient management. Chemical design and bacterial targeting mechanisms are the basis for the specificity of such tracers. The aim of this review is to provide a comprehensive overview of the molecular imaging tracers developed for optical and nuclear identification of bacteria and bacterial infections. Hereby we envision that such tracers can be used to diagnose infections and aid their clinical management. From these compounds we have set-out to identify promising targeting mechanisms and select the most promising candidates for further development.en_US
dc.description.librarianhb2014en_US
dc.description.sponsorshipThe Netherlands Organisation for Scientific Research (NWO; STW BGT 11272).en_US
dc.description.urihttp://pubs.acs.org/bcen_US
dc.identifier.citationBunschoten, A, Welling, MM, Termaat, MF, Sathekge, MM & Van Leeuwen FWB 2013, ' Development and prospects of dedicated tracers for the molecular imaging of bacterial infections', Bioconjugate Chemistry, vol. 24, no. 12, pp. 1971-1989.en_US
dc.identifier.issn1043-1802 (print)
dc.identifier.issn1520-4812 (online)
dc.identifier.other10.1021/bc4003037
dc.identifier.urihttp://hdl.handle.net/2263/40062
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.rights© 2013 American Chemical Societyen_US
dc.subjectDedicated tracersen_US
dc.subjectMolecular imagingen_US
dc.subjectBacterial infectionsen_US
dc.titleDevelopment and prospects of dedicated tracers for the molecular imaging of bacterial infectionsen_US
dc.typePostprint Articleen_US

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