Discovery : an interactive resource for the rational selection and comparison of putative drug target proteins in malaria

dc.contributor.authorJoubert, Fourie
dc.contributor.authorHarrison, Claudia M.
dc.contributor.authorKoegelenberg, Riaan J.
dc.contributor.authorOdendaal, Christiaan J.
dc.contributor.authorDe Beer, T.A.P. (Tjaart Andries Petrus)
dc.contributor.emailfourie.joubert@up.ac.zaen
dc.date.accessioned2010-03-19T09:30:18Z
dc.date.available2010-03-19T09:30:18Z
dc.date.issued2009-07
dc.description.abstractBACKGROUND: Up to half a billion human clinical cases of malaria are reported each year, resulting in about 2.7 million deaths, most of which occur in sub-Saharan Africa. Due to the over-and misuse of anti-malarials, widespread resistance to all the known drugs is increasing at an alarming rate. Rational methods to select new drug target proteins and lead compounds are urgently needed. The Discovery system provides data mining functionality on extensive annotations of five malaria species together with the human and mosquito hosts, enabling the selection of new targets based on multiple protein and ligand properties. METHODS: A web-based system was developed where researchers are able to mine information on malaria proteins and predicted ligands, as well as perform comparisons to the human and mosquito host characteristics. Protein features used include: domains, motifs, EC numbers, GO terms, orthologs, protein-protein interactions, protein-ligand interactions and host-pathogen interactions among others. Searching by chemical structure is also available. RESULTS: An in silico system for the selection of putative drug targets and lead compounds is presented, together with an example study on the bifunctional DHFR-TS from Plasmodium falciparum. CONCLUSION: The Discovery system allows for the identification of putative drug targets and lead compounds in Plasmodium species based on the filtering of protein and chemical properties.en
dc.description.urihttp://www.malariajournal.com/content/8/1/178en
dc.identifier.citationJoubert, F, Harrison, CN, Koegelenberg, RJ, Odendaal, CJ & De Beer, TAP 2009, 'Discovery: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria', Malaria Journal, vol. 8, no. 178, pp. 1-8. [http://www.malariajournal.com/]en
dc.identifier.issn1475-2875
dc.identifier.other10.1186/1475-2875-8-178
dc.identifier.urihttp://hdl.handle.net/2263/13589
dc.language.isoenen
dc.publisherBioMed Centralen
dc.rights© 2009 Joubert et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectDiscovery systemen
dc.subject.lcshMalariaen
dc.subject.lcshInteractive computer systemsen
dc.subject.lcshDrug targetingen
dc.subject.lcshProteins -- Analysisen
dc.subject.lcshPlasmodiumen
dc.subject.lcshLead compoundsen
dc.titleDiscovery : an interactive resource for the rational selection and comparison of putative drug target proteins in malariaen
dc.typeArticleen

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Joubert_Discovery(2009).pdf
Size:
543.02 KB
Format:
Adobe Portable Document Format
Description:
Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
2.44 KB
Format:
Item-specific license agreed upon to submission
Description: