In vitro and in vivo evaluation of an oral multi-layered multi-disk tablet for specialized chronotherapeutic drug delivery

dc.contributor.authorKhan, Zaheeda
dc.contributor.authorGovender, Mershen
dc.contributor.authorIndermun, Sunaina
dc.contributor.authorKumar, Pradeep
dc.contributor.authorChoonara, Yahya E.
dc.contributor.authorDu Toit, Lisa C.
dc.contributor.authorMeyer, Leith Carl Rodney
dc.contributor.authorPillay, Viness
dc.date.accessioned2019-03-04T09:08:43Z
dc.date.issued2018-06
dc.description.abstractChronotherapeutic disorders such as hypertension, cardiovascular disease and asthma commonly involve the use of controlled zero-order release formulations. Ideally, the required drug should be released at predetermined rates with two or more pulses released from the dosage form. This ultimately exposes the patient to drug only when required, reducing the number of dosages, reducing side-effects and increasing patient compliance. The aim of this research was to evaluate two Multi-Layered Multi-Disk Tablet (MLMDT) systems incorporating drug-loaded disks enveloped by three polymeric layers. The model drugs used for each system were theophylline and diltiazem hydrochloride. The proposed chronotherapeutic system was designed to provide a lag phase and then two pulses of drug release separated by a ‘switch-off’ phase. In vitro drug release analysis revealed that the MLMDT generated a lag phase or a ‘switch-off’ phase followed by two pulses of drug release over the evaluated 24 h period. In vivo testing was undertaken using a Large White Pig Model, where concentration analysis from the evaluated conventional products revealed increasing plasma concentrations up to 2 h followed by a steady decline in concentration while the developed MLMDT displayed two pulse prolonged drug release profile separated by a switch-off phase.en_ZA
dc.description.departmentParaclinical Sciencesen_ZA
dc.description.embargo2019-06-01
dc.description.librarianhj2019en_ZA
dc.description.sponsorshipThe National Research Foundation (NRF) of South Africa.en_ZA
dc.description.urihttp://www.elsevier.com/locate/jddsten_ZA
dc.identifier.citationKhan, Z., Govender, M., Indermun, S. et al. 2018, 'In vitro and in vivo evaluation of an oral multi-layered multi-disk tablet for specialized chronotherapeutic drug delivery', Journal of Drug Delivery Science and Technology, vol. 45, pp. 39-44.en_ZA
dc.identifier.issn0165-1889 (print)
dc.identifier.issn1879-1743 (online)
dc.identifier.other10.1016/j.jddst.2018.03.001
dc.identifier.urihttp://hdl.handle.net/2263/68545
dc.language.isoenen_ZA
dc.publisherElsevieren_ZA
dc.rights© Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Journal of Drug Delivery Science and Technology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Journal of Drug Delivery Science and Technology, vol. 45, pp. 39-44, 2018. doi : 10.1016/j.jddst.2018.03.001.en_ZA
dc.subjectChronotherapeuticsen_ZA
dc.subjectMulti-layered multi-disk tablet (MLMDT)en_ZA
dc.subjectDrug deliveryen_ZA
dc.subjectSwitch-off phaseen_ZA
dc.subjectMetabolismen_ZA
dc.subjectPigsen_ZA
dc.titleIn vitro and in vivo evaluation of an oral multi-layered multi-disk tablet for specialized chronotherapeutic drug deliveryen_ZA
dc.typePostprint Articleen_ZA

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