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Erythrocyte–platelet interaction in uncomplicated pregnancy

dc.contributor.authorSwanepoel, A.C. (Albe Carina)
dc.contributor.authorPretorius, Etheresia
dc.date.accessioned2015-06-25T09:04:40Z
dc.date.available2015-06-25T09:04:40Z
dc.date.issued2014-12
dc.description.abstractMaternal and fetal requirements during uncomplicated pregnancy are associated with changes in the hematopoietic system. Platelets and erythrocytes [red blood cells (RBCs)], and especially their membranes, are involved in coagulation, and their interactions may provide reasons for the changed hematopoietic system during uncomplicated pregnancy.We review literature regarding RBC and platelet membrane structure and interactions during hypercoagulability and hormonal changes. We then study interactions between RBCs and platelets in uncomplicated pregnancy, as their interactions may be one of the reasons for increased hypercoagulability during uncomplicated pregnancy. Scanning electronmicroscopy was used to study whole blood smears from90 pregnant females in different phases of pregnancy. Pregnancy-specific interaction was seen between RBCs and platelets. Typically, one or more platelets interacted through platelet spreading and pseudopodia formation with a single RBC. However, multiple interactions with RBCs were also shown for a single platelet. Specific RBC–platelet interaction seen during uncomplicated pregnancy may be caused by increased estrogen and/or increased fibrinogen concentrations. This interaction may contribute to the hypercoagulable state associated with healthy and uncomplicated pregnancy and may also play a fundamental role in gestational thrombocytopenia.en_ZA
dc.description.embargo2015-12-30en_ZA
dc.description.librarianhb2015en_ZA
dc.description.urihttp://journals.cambridge.org/action/displayJournal?jid=MAMen_ZA
dc.identifier.citationSwanepoel, AC & Pretorius, E 2014, 'Erythrocyte–platelet interaction in uncomplicated pregnancy', Microscopy and Microanalysis, vol. 20, no. 6, pp. 1848-1860.en_ZA
dc.identifier.issn1431-9276 (print
dc.identifier.issn1435-8115 (online)
dc.identifier.other10.1017/S1431927614013518
dc.identifier.urihttp://hdl.handle.net/2263/45781
dc.language.isoenen_ZA
dc.publisherCambridge University Pressen_ZA
dc.rights© Microscopy Society of America 2014en_ZA
dc.subjectUncomplicated pregnancyen_ZA
dc.subjectErythrocytesen_ZA
dc.subjectPlateletsen_ZA
dc.subjectScanning electron microscopyen_ZA
dc.subjectRed blood cells (RBCs)en_ZA
dc.titleErythrocyte–platelet interaction in uncomplicated pregnancyen_ZA
dc.typePostprint Articleen_ZA

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