Urban leptospirosis in Africa : a cross-sectional survey of leptospira infection in rodents in the Kibera urban settlement, Nairobi, Kenya

dc.contributor.authorHalliday, JoE.B.
dc.contributor.authorKnobel, Darryn Leslie
dc.contributor.authorAllan, Kathryn J.
dc.contributor.authorDe Bronsvoort, B.M.C.
dc.contributor.authorHandel, Ian Graham
dc.contributor.authorAgwanda, Bernard
dc.contributor.authorCutler, Sally J.
dc.contributor.authorOlack, Beatrice
dc.contributor.authorAhmed, Ahmed
dc.contributor.authorHartskeerl, Rudy A.
dc.contributor.authorNjenga, M. Kariuki
dc.contributor.authorCleaveland, Sarah
dc.contributor.authorBreiman, Robert F.
dc.contributor.emaildarryn.knobel@up.ac.zaen
dc.date.accessioned2014-02-26T08:32:06Z
dc.date.available2014-02-26T08:32:06Z
dc.date.issued2013-09-30
dc.description.abstractLeptospirosis is a widespread but under-reported cause of morbidity and mortality. Global re-emergence of leptospirosis has been associated with the growth of informal urban settlements in which rodents are thought to be important reservoir hosts. Understanding the multi-host epidemiology of leptospirosis is essential to control and prevent disease. A cross-sectional survey of rodents in the Kibera settlement in Nairobi, Kenya was conducted in September– October 2008 to demonstrate the presence of pathogenic leptospires. A real-time quantitative polymerase chain reaction showed that 41 (18.3%) of 224 rodents carried pathogenic leptospires in their kidneys, and sequence data identified Leptospira interrogans and L. kirschneri in this population. Rodents of the genus Mus (37 of 185) were significantly more likely to be positive than those of the genus Rattus (4 of 39; odds ratio = 15.03). Questionnaire data showed frequent contact between humans and rodents in Kibera. This study emphasizes the need to quantify the public health impacts of this neglected disease at this and other urban sites in Africa.en
dc.description.librarianam2014en
dc.description.librarianab2014
dc.description.sponsorshipThe Wellcome Trust, United Kingdom (grants 081828/B/06/Z and 096400/Z/11/Z), the Biotechnology and Biological Sciences Research Council, United Kingdom (grant BB/J010367/1) and the Medical Research Council, United Kingdom (grant G0902417 94378).en
dc.identifier.citationHalliday, JEB, Knobel, DL, Allan, KJ, De Bronsvoort, BMC, Handel, I, Agwanda, B, Cutler, SJ, Olack, B, Ahmed, A, Hartskeerl, RA, Njenga, MK, Cleaveland, S & Breiman, RF 2013, 'Urban Leptospirosis in Africa : a cross-sectional survey of Leptospira infection in rodents in the Kibera urban settlement, Nairobi, Kenya', American Journal of Tropical Medicine and Hygiene, vol. 89, no. 6, pp. 1095-1102.en
dc.identifier.issn0002-9637 (print)
dc.identifier.issn1476-1645 (online)
dc.identifier.other10.4269/ajtmh.13-0415
dc.identifier.other6602518021
dc.identifier.otherO-7057-2014
dc.identifier.other0000-0002-0425-3799
dc.identifier.urihttp://hdl.handle.net/2263/36756
dc.language.isoenen
dc.publisherAmerican Society of Tropical Medicine and Hygieneen
dc.relation.requiresAdobe Acrobat Readeren
dc.rights© 2013 by The American Society of Tropical Medicine and Hygieneen
dc.subjectLeptospirosisen
dc.subjectAfricaen
dc.subjectLeptospira infectionen
dc.subjectRodentsen
dc.subjectKibera urban settlement, Nairobi, Kenyaen
dc.subject.lcshLeptospirosis in animals -- Kenyaen
dc.subject.lcshBacterial diseases in animalsen
dc.subject.lcshRodents -- Diseasesen
dc.subject.lcshRodents as carriers of disease -- Kenyaen
dc.titleUrban leptospirosis in Africa : a cross-sectional survey of leptospira infection in rodents in the Kibera urban settlement, Nairobi, Kenyaen
dc.typeArticleen

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