Mathematical model and experimental study on transient temperature profiles around a cylindrical heat source inside an in vitro tissue

dc.contributor.authorHong, Jan-Chen
dc.contributor.authorLin, Xi-Zhang
dc.contributor.authorLee, Po-Sheng
dc.contributor.authorLee, Meng-Ta
dc.date.accessioned2015-09-15T09:27:25Z
dc.date.available2015-09-15T09:27:25Z
dc.date.issued2010
dc.description.abstractPaper presented at the 7th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Turkey, 19-21 July, 2010.en_ZA
dc.description.abstractIn treatment of tumor by hyperthermia, the temperature profile around the heat source is the major factor influencing the effect of hyperthermia. In this study, a mathematical model of the transient temperature profiles around a cylindrical heat source inside an in vitro tissue has been developed. Experiments with an in vitro pork liver have been conducted to study the change of liver temperature around a nickel­-chromium alloy wire heated by direct current at fixed power. Computer simulation of the mathematical model can be used to help doctors to predict the change of temperature profiles in the tissue during thermal therapy The results show that liver temperature near the heating source can be controlled in a desired range for hyperthermia, say, 45-70 "C, by a simple on-off control of the power of heat source. For example, heating power is switched on for 300 seconds firstly, then off and on each for 50 seconds repeatedly. The results also show that as the distance from the heat source increases, the tissue temperature decreases, and the magnitude of temperature oscillation due to power off and on decreases too. There are two parameters, thermal conductivity (k) and heat transfer coefficient (h), in the mathematical model. It has been found that there exists a zone, in the range of 0.66≤k≤0.74 W/m-K and 130≤h≤155 W/m2-K, where the average error between mathematical model and experimental model is less than 2.40"C. When temperature dependency of thermal conductivity, k=0.4981+0.0008T, is considered, there exists a minimum of average error of 2.59 "C at h 210 W/m2-K. However, for a wide range of heat transfer coefficient between !50 and 280 W/m-K, the average error is less than 3"C.
dc.description.librarianej2015en_ZA
dc.format.extent5 Pagesen_ZA
dc.format.mediumPDFen_ZA
dc.identifier.citationHong, J, Lin, X, Lee, P & Lee, M 2010, 'Mathematical model and experimental study on transient temperature profiles around a cylindrical heat source inside an in vitro tissue', Paper presented to the 7th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Turkey, 19-21 July 2010.en_ZA
dc.identifier.urihttp://hdl.handle.net/2263/49893
dc.language.isoenen_ZA
dc.publisherInternational Conference on Heat Transfer, Fluid Mechanics and Thermodynamicsen_ZA
dc.relation.ispartofHEFAT 2010en_US
dc.rightsUniversity of Pretoriaen_ZA
dc.subjectVitro tissueen_ZA
dc.titleMathematical model and experimental study on transient temperature profiles around a cylindrical heat source inside an in vitro tissueen_ZA
dc.typePresentationen_ZA

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