The effect of three bufadienolide cardiac glycosides on contraction of isolated rat jejunum
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Date
Authors
Botha, C.J. (Christoffel Jacobus)
Gehring, Ronette
Van Rooyen, J.M.
Venter, D.
Journal Title
Journal ISSN
Volume Title
Publisher
Published jointly by the Agricultural Research Council, ARC-Onderstepoort Veterinary Institute and the Faculty of Veterinary Science, University of Pretoria.
Abstract
Three cardiac glycosides were screened for pharmacological effects on isolated rat jejunum. The contraction of rat jejunum with epoxyscillirosidin, a non-cumulative bufadienolide, and cotyledoside and tyledoside D, both cumulative neurotoxic bufadienolides were compared with methacholine. The results indicate that all three bufadienolides cause contraction of jejunal smooth muscle. When combined with atropine (1X10ˉ⁶ M) the response of epoxyscillirosidin and tyledoside D decreased, indicating suppression of a cholinergic response caused by the cardiac glycosides.
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Keywords
Veterinary medicine, Bufadienolide, Cardiac glycosides, Cotyledoside, Epoxyscillirosidin, Methacholine, Rat jejunum, Tyledoside D
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Citation
Botha, CJ, Gehring, R, Van Rooyen, JM & Venter, D 2002, 'The effect of three bufadienolide cardiac glycosides on contraction of isolated rat jejunum’. Onderstepoort Journal of Veterinary Research, vol. 69, no. 3, pp. 243-246.