Spatial analyses of immune cell infiltration in cancer : current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer

dc.contributor.authorPage, David B.
dc.contributor.authorBroeckx, Glenn
dc.contributor.authorJahangir, Chowdhury Arif
dc.contributor.authorVerbandt, Sara
dc.contributor.authorGupta, Rajarsi R.
dc.contributor.authorThagaard, Jeppe
dc.contributor.authorKhiroya, Reena
dc.contributor.authorKos, Zuzana
dc.contributor.authorAbduljabbar, Khalid
dc.contributor.authorAcosta Haab, Gabriela
dc.contributor.authorAcs, Balazs
dc.contributor.authorAlmeida, Jonas S.
dc.contributor.authorAlvarado-Cabrero, Isabel
dc.contributor.authorAzmoudeh-Ardalan, Farid
dc.contributor.authorBadve, Sunil
dc.contributor.authorBaharun, Nurkhairul Bariyah
dc.contributor.authorBellolio, Enrique R.
dc.contributor.authorBheemaraju, Vydehi
dc.contributor.authorBlenman, Kim R.M.
dc.contributor.authorBotinelly Mendonca Fujimoto, Luciana
dc.contributor.authorBurgues, Octavio
dc.contributor.authorCheang, Maggie Chon U.
dc.contributor.authorCiompi, Francesco
dc.contributor.authorCooper, Lee A.D.
dc.contributor.authorCoosemans, An
dc.contributor.authorCorredor, German
dc.contributor.authorDantas Portela, Flavio Luis
dc.contributor.authorDeman, Frederik
dc.contributor.authorDemaria, Sandra
dc.contributor.authorDudgeon, Sarah N.
dc.contributor.authorElghazawy, Mahmoud
dc.contributor.authorEly, Scott
dc.contributor.authorFernandez-Martin, Claudio
dc.contributor.authorFineberg, Susan
dc.contributor.authorFox, Stephen B.
dc.contributor.authorGallagher, William M.
dc.contributor.authorGiltnane, Jennifer M.
dc.contributor.authorGnjatic, Sacha
dc.contributor.authorGonzalez-Ericsson, Paula I.
dc.contributor.authorGrigoriadis, Anita
dc.contributor.authorHalama, Niels
dc.contributor.authorHanna, Matthew G.
dc.contributor.authorHarbhajanka, Aparna
dc.contributor.authorHardas, Alexandros
dc.contributor.authorHart, Steven N.
dc.contributor.authorHartman, Johan
dc.contributor.authorHewitt, Stephen
dc.contributor.authorHida, Akira I.
dc.contributor.authorHorlings, Hugo M.
dc.contributor.authorHusain, Zaheed
dc.contributor.authorHytopoulos, Evangelos
dc.contributor.authorIrshad, Sheeba
dc.contributor.authorJanssen, Emiel A.M.
dc.contributor.authorKahila, Mohamed
dc.contributor.authorKataoka, Tatsuki R.
dc.contributor.authorKawaguchi, Kosuke
dc.contributor.authorKharidehal, Durga
dc.contributor.authorKhramtsov, Andrey I.
dc.contributor.authorKiraz, Umay
dc.contributor.authorKirtani, Pawan
dc.contributor.authorKodach, Liudmila L.
dc.contributor.authorKorski, Konstanty
dc.contributor.authorKovacs, Aniko
dc.contributor.authorLaenkholm, Anne-Vibeke
dc.contributor.authorLang-Schwarz, Corinna
dc.contributor.authorLarsimont, Denis
dc.contributor.authorLennerz, Jochen K.
dc.contributor.authorLerousseau, Marvin
dc.contributor.authorLi, Xiaoxian
dc.contributor.authorLy, Amy
dc.contributor.authorMadabhushi, Anant
dc.contributor.authorMaley, Sai K.
dc.contributor.authorManur Narasimhamurthy, Vidya
dc.contributor.authorMarks, Douglas K.
dc.contributor.authorMcDonald, Elizabeth S.
dc.contributor.authorMehrotra, Ravi
dc.contributor.authorMichiels, Stefan
dc.contributor.authorMinhas, Fayyaz ul Amir Afsar
dc.contributor.authorMittal, Shachi
dc.contributor.authorMoore, David A.
dc.contributor.authorMushtaq, Shamim
dc.contributor.authorNighat, Hussain
dc.contributor.authorPapathomas, Thomas
dc.contributor.authorPenault-Llorca, Frederique
dc.contributor.authorPerera, Rashindrie D.
dc.contributor.authorPinard, Christopher J.
dc.contributor.authorPinto-Cardenas, Juan Carlos
dc.contributor.authorPruneri, Giancarlo
dc.contributor.authorPusztai, Lajos
dc.contributor.authorRahman, Arman
dc.contributor.authorRajpoot, Nasir Mahmood
dc.contributor.authorRapoport, Bernardo Leon
dc.contributor.authorRau, Tilman T.
dc.contributor.authorReis-Filho, Jorge S.
dc.contributor.authorRibeiro, Joana M.
dc.contributor.authorRimm, David
dc.contributor.authorSalomon, Anne-Vincent
dc.contributor.authorSalto-Tellez, Manuel
dc.contributor.authorSaltz, Joel
dc.contributor.authorSayed, Shahin
dc.contributor.authorSiziopikou, Kalliopi P.
dc.contributor.authorSotiriou, Christos
dc.contributor.authorStenzinger, Albrecht
dc.contributor.authorSughayer, Maher A.
dc.contributor.authorSur, Daniel
dc.contributor.authorSymmans, Fraser
dc.contributor.authorTanaka, Sunao
dc.contributor.authorTaxter, Timothy
dc.contributor.authorTejpar, Sabine
dc.contributor.authorTeuwen, Jonas
dc.contributor.authorThompson, E. Aubrey
dc.contributor.authorTramm, Trine
dc.contributor.authorTran, William T.
dc.contributor.authorVan Der Laak, Jeroen
dc.contributor.authorVan Diest, Paul J.
dc.contributor.authorVerghese, Gregory E.
dc.contributor.authorViale, Giuseppe
dc.contributor.authorVieth, Michael
dc.contributor.authorWahab, Noorul
dc.contributor.authorWalter, Thomas
dc.contributor.authorWaumans, Yannick
dc.contributor.authorWen, Hannah Y.
dc.contributor.authorYang, Wentao
dc.contributor.authorYuan, Yinyin
dc.contributor.authorAdams, Sylvia
dc.contributor.authorBartlett, John Mark Seaverns
dc.contributor.authorLoibl, Sibylle
dc.contributor.authorDenkert, Carsten
dc.contributor.authorSavas, Peter
dc.contributor.authorLoi, Sherene
dc.contributor.authorSalgado, Roberto
dc.contributor.authorSpecht Stovgaard, Elisabeth
dc.contributor.authorAkturk, Guray
dc.contributor.authorBouchmaa, Najat
dc.date.accessioned2024-06-20T11:10:03Z
dc.date.available2024-06-20T11:10:03Z
dc.date.issued2023-08
dc.description.abstractModern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized method for describing or analyzing spatial immune cell data, and most reported spatial analyses are rudimentary. In this review, we provide an overview of two approaches for reporting and analyzing spatial data (raster versus vector-based). We then provide a compendium of spatial immune cell metrics that have been reported in the literature, summarizing prognostic associations in the context of a variety of cancers. We conclude by discussing two well-described clinical biomarkers, the breast cancer stromal tumor infiltrating lymphocytes score and the colon cancer Immunoscore, and describe investigative opportunities to improve clinical utility of these spatial biomarkers. © 2023 The Pathological Society of Great Britain and Ireland.en_US
dc.description.departmentImmunologyen_US
dc.description.librarianhj2024en_US
dc.description.sdgSDG-03:Good heatlh and well-beingen_US
dc.description.urihttp://www.thejournalofpathology.com/en_US
dc.identifier.citationPage, D.B., Broeckx, G., Jahangir, C.A. et al. 2024, 'Spatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer', Journal of Pathology, vol. 260, no. 5, pp. 514-532, doi : 10.1002/path.6165.en_US
dc.identifier.issn0022-3417 (print)
dc.identifier.issn1096-9896 (online)
dc.identifier.other10.1002/path.6165
dc.identifier.urihttp://hdl.handle.net/2263/96563
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rights© 2023 The Pathological Society of Great Britain and Ireland.en_US
dc.subjectSpatial statisticsen_US
dc.subjectTumor infiltrating lymphocytes (TIL)en_US
dc.subjectStromal tumor infiltrating lymphocytes (sTIL) scoreen_US
dc.subjectImmunoscoreen_US
dc.subjectMultispectral immunofluorescenceen_US
dc.subjectSpatial heterogeneityen_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.titleSpatial analyses of immune cell infiltration in cancer : current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Canceren_US
dc.typeArticleen_US

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