Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration

dc.contributor.authorSonigo, Charlotte
dc.contributor.authorBouilly, Justine
dc.contributor.authorCarre, Nadège
dc.contributor.authorTolle, Virginie
dc.contributor.authorCaraty, Alain
dc.contributor.authorTello, Javier A.
dc.contributor.authorSimony-Conesa, Fabian-Jesus
dc.contributor.authorMillar, Robert P.
dc.contributor.authorYoung, Jacques
dc.contributor.authorBinart, Nadine
dc.date.accessioned2012-11-28T07:16:41Z
dc.date.available2012-11-28T07:16:41Z
dc.date.issued2012-10
dc.description.abstractHyperprolactinemia is the most common cause of hypogonadotropic anovulation and is one of the leading causes of infertility in women aged 25–34. Hyperprolactinemia has been proposed to block ovulation through inhibition of GnRH release. Kisspeptin neurons, which express prolactin receptors, were recently identified as major regulators of GnRH neurons. To mimic the human pathology of anovulation, we continuously infused female mice with prolactin. Our studies demonstrated that hyperprolactinemia in mice induced anovulation, reduced GnRH and gonadotropin secretion, and diminished kisspeptin expression. Kisspeptin administration restored gonadotropin secretion and ovarian cyclicity, suggesting that kisspeptin neurons play a major role in hyperprolactinemic anovulation. Our studies indicate that administration of kisspeptin may serve as an alternative therapeutic approach to restore the fertility of hyperprolactinemic women who are resistant or intolerant to dopamine agonists.en_US
dc.description.sponsorshipR. Millar is recipient of a grant from the Medical Research Council (South Africa) and the University of Pretoria.en_US
dc.description.urihttp://www.jci.orgen_US
dc.identifier.citationSonigo, C, Bouilly, J, Carre, N, Tolle, V, Caraty, A, Tello, J, Simony-Conesa, FJ, Millar, R, Young, J & Binart, N 2012, 'Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration', Journal of Clinical Investigation, vol. 122, no. 10, pp. 3791–3795, doi:10.1172/JCI63937.en_US
dc.identifier.issn0021-9738 (print)
dc.identifier.issn1558-8238 (online)
dc.identifier.other10.1172/JCI63937
dc.identifier.urihttp://hdl.handle.net/2263/20551
dc.language.isoenen_US
dc.publisherAmerican Society for Clinical Investigationen_US
dc.rightsAmerican Society for Clinical Investigationen_US
dc.subjectHyperprolactinemiaen_US
dc.subjectKisspeptinen_US
dc.titleHyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administrationen_US
dc.typeArticleen_US

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