Improved understanding of the pathophysiology of sepsis : setting the scene for potential novel adjunctive therapies

dc.contributor.authorChausse, J.M.
dc.contributor.authorMalekele, L.
dc.contributor.authorParuk, Fathima
dc.contributor.emailfathima.paruk@up.ac.zaen_ZA
dc.date.accessioned2019-08-08T09:28:57Z
dc.date.available2019-08-08T09:28:57Z
dc.date.issued2018
dc.description.abstractThe occurrence of sepsis in the critically ill population is a dreaded phenomenon when taking into consideration the devastating complications associated with the disease. Despite its high incidence and unacceptably high mortality, this complex syndrome remains poorly understood in terms of defining the disease, detecting the presence or absence of an infection, and therapeutic strategies to optimise immediate and long-term outcomes. Global efforts to address these issues coupled with significant advances in medical technologies and our improved understanding of the pathophysiology of the disease have led to some exciting developments in the domain of adjunctive therapies for sepsis. In particular, interest has focused around immunomodulation strategies and metabolic resuscitation. Some of these therapies sound particularly promising in terms of the early available evidence. The concept of personalised or individualised medicine takes centre stage when considering such therapies, as it is becoming increasingly evident that in order to achieve benefits, we need to introduce appropriate therapies at the right time, the right dose and for an appropriate duration. This review encapsulates a selection of these new adjunctive therapies.en_ZA
dc.description.departmentCritical Careen_ZA
dc.description.librarianam2019en_ZA
dc.description.urihttp://www.sajcc.org.zaen_ZA
dc.identifier.citationChausse, J.M., Malekele, L. & Paruk F. 2019, 'Improved understanding of the pathophysiology of sepsis : setting the scene for potential novel adjunctive therapies', Southern African Journal of Critical Care, vol. 34, no. 1, pp. 4-8.en_ZA
dc.identifier.issn1562-8264 (print)
dc.identifier.issn2078-676X (online)
dc.identifier.other10.7196/SAJCC.201.v34i1.361
dc.identifier.urihttp://hdl.handle.net/2263/70923
dc.language.isoenen_ZA
dc.publisherHealth and Medical Publishing Groupen_ZA
dc.rights© 2018. The Authors. Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.en_ZA
dc.subjectSepsisen_ZA
dc.subjectMortalityen_ZA
dc.subjectMedical technologiesen_ZA
dc.subjectTherapiesen_ZA
dc.subjectPathophysiologyen_ZA
dc.titleImproved understanding of the pathophysiology of sepsis : setting the scene for potential novel adjunctive therapiesen_ZA
dc.typeArticleen_ZA

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