Deep eutectic solvents for solid pesticide dosage forms

dc.contributor.authorPhillips, Justin
dc.contributor.authorFocke, Walter Wilhelm
dc.contributor.authorDu Toit, Elizabeth Louisa
dc.contributor.authorWesley‑Smith, James
dc.contributor.emailwalter.focke@up.ac.zaen_ZA
dc.date.accessioned2021-07-28T13:24:38Z
dc.date.available2021-07-28T13:24:38Z
dc.date.issued2020-11-26
dc.description.abstractDeep eutectic solvents aid the formulation of solid pesticide dosage forms for water-insoluble actives. This was demonstrated by encapsulating Amitraz powder in a low-melting matrix based on the eutectic mixture of urea (32 wt%) and 1,3-dimethylurea. Dissolution in water of melt-cast discs, containing 20 wt% active, led to the rapid release of Amitraz in a finely dispersed form. The order of magnitude reduction in particle size, after dissolution, is ascribed to the solubilization of Amitraz in the hot deep eutectic solvent and its subsequent precipitation as a separate phase on crystallization of the matrix.en_ZA
dc.description.departmentChemical Engineeringen_ZA
dc.description.librarianam2021en_ZA
dc.description.sponsorshipThe Institute of Applied Materials, University of Pretoriaen_ZA
dc.description.urihttp://www.nature.com/srepen_ZA
dc.identifier.citationPhillips, J., Focke, W.W., Du Toit, E.L. et al. 2020, 'Deep eutectic solvents for solid pesticide dosage forms', Scientific Reports, vol. 10, art. 20729, pp. 1-6.en_ZA
dc.identifier.issn2045-2322 (online)
dc.identifier.other10.1038/s41598-020-77559-0
dc.identifier.urihttp://hdl.handle.net/2263/81039
dc.language.isoenen_ZA
dc.publisherNature Publishing Groupen_ZA
dc.rights© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License.en_ZA
dc.subjectWater-insolubleen_ZA
dc.subjectAmitraz powderen_ZA
dc.subjectEutectic mixtureen_ZA
dc.subjectUreaen_ZA
dc.titleDeep eutectic solvents for solid pesticide dosage formsen_ZA
dc.typeArticleen_ZA

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