The utility of metabolic parameters on baseline F-18 FDG PET/CT in predicting treatment response and survival in paediatric and adolescent Hodgkin lymphoma

dc.contributor.authorReed, Janet D.
dc.contributor.authorMasenge, Andries
dc.contributor.authorBuchner, Ane
dc.contributor.authorOmar, Fareed E.
dc.contributor.authorReynders, David
dc.contributor.authorVorster, Mariza
dc.contributor.authorVan de Wiele, Christophe
dc.contributor.authorSathekge, Mike Machaba
dc.contributor.emailmike.sathekge@up.ac.zaen_US
dc.date.accessioned2022-09-02T13:05:25Z
dc.date.available2022-09-02T13:05:25Z
dc.date.issued2021-12-20
dc.description.abstractLymphoma is the third most common paediatric cancer. Early detection of high-risk patients is necessary to anticipate those who require intensive therapy and follow-up. Current literature shows that residual tumor avidity on PET (Positron Emission Tomography) following chemotherapy corresponds with decreased survival. However, the value of metabolic parameters has not been adequately investigated. In this retrospective study, we aimed to evaluate the prognostic value of metabolic and other parameters in paediatric and adolescent Hodgkin lymphoma. We recorded tMTV (total Metabolic Tumor Volume), TLG (Total Lesion Glycolysis), and SUVmax (maximum Standard Uptake Value) on baseline PET, as well the presence of bone marrow or visceral involvement. HIV (human immunodeficiency virus) status and baseline biochemistry from clinical records were noted. All patients received stage-specific standard of care therapy. Response assessment on end-of-treatment PET was evaluated according to the Deauville criteria. We found that bone marrow involvement (p = 0.028), effusion (p < 0.001), and treatment response (p < 0.001) on baseline PET, as well as HIV status (p = 0.036) and baseline haemoglobin (p = 0.039), were significantly related to progression-free survival (PFS), whereas only effusion (p = 0.017) and treatment response (p = 0.050) were predictive of overall survival (OS). Only baseline tMTV predicted treatment response (p = 0.017). This confirms the value of F-18 FDG PET/CT (Fluoro-deoxy-glucose Positron Emission Tomography/ Computed Tomography) in prognostication in paediatric and adolescent Hodgkin lymphoma; however, further studies are required to define the significance of metabolic parameters.en_US
dc.description.departmentMedical Oncologyen_US
dc.description.departmentNuclear Medicineen_US
dc.description.departmentStatisticsen_US
dc.description.librarianam2022en_US
dc.description.urihttps://www.mdpi.com/journal/jcmen_US
dc.identifier.citationReed, J.D.; Masenge, A.; Buchner, A.; Omar, F.; Reynders, D.; Vorster, M.; Van de Wiele, C.; Sathekge, M. The Utility of Metabolic Parameters on Baseline F-18 FDG PET/CT in Predicting Treatment Response and Survival in Paediatric and Adolescent Hodgkin Lymphoma. J. Clin. Med. 2021, 10, 5979. https:// DOI.org/ 10.3390/jcm10245979en_US
dc.identifier.issn2077-0383 (online)
dc.identifier.other10.3390/jcm10245979
dc.identifier.urihttps://repository.up.ac.za/handle/2263/87056
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_US
dc.subjectMetabolic parametersen_US
dc.subjectTotal metabolic tumor volume (tMTV)en_US
dc.subjectTotal lesion glycolysis (TLG)en_US
dc.subjectMaximum standard uptake value (SUVmax)en_US
dc.subjectPaediatric oncologyen_US
dc.subjectHodgkin lymphoma (HL)en_US
dc.subjectOverall survival (OS)en_US
dc.subjectProgression-free survival (PFS)en_US
dc.subjectHuman immunodeficiency virus (HIV)en_US
dc.subjectF-18 FDG PET/CTen_US
dc.titleThe utility of metabolic parameters on baseline F-18 FDG PET/CT in predicting treatment response and survival in paediatric and adolescent Hodgkin lymphomaen_US
dc.typeArticleen_US

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