Evaluating the utility of a point-of-care glucometer for the diagnosis of gestational diabetes

dc.contributor.authorAdam, Sumaiya
dc.contributor.authorRheeder, Paul
dc.contributor.emailsumaiya.adam@up.ac.zaen_ZA
dc.date.accessioned2018-02-15T11:16:27Z
dc.date.issued2018-04
dc.description.abstractOBJECTIVE : To investigate the performance of the Roche Accuchek Active glucometer in diagnosing gestational diabetes mellitus (GDM) versus the gold-standard laboratory test. METHODS : In a prospective cohort observational study at a primary healthcare clinic in Johannesburg, South Africa, pregnant women, excluding known diabetics, were recruited between 2013 and 2016. A 75-g 2-hour oral glucose tolerance test (OGTT) was scheduled at 24–28 gestational weeks. Glucose was measured in venous blood (laboratory) and capillary blood (glucometer). GDM was diagnosed via FIGO criteria. Diagnostic accuracy was evaluated by calculating the sensitivity, specificity, and coefficient of variance (CV) of the glucometer test, and by Bland-Altman plots. RESULTS : Data from 529 women were analyzed. Of these, 141 (26.7%) and 79 (14.9%) were diagnosed with GDM by laboratory and glucometer measurements, respectively. The CV of the glucometer ranged from 15% to 17%. Bland-Altman plots showed a positive bias of the glucometer results at 0 hours, but a negative bias at 1 and 2 hours of the OGTT. The sensitivity and specificity of the glucometer for the diagnosis of GDM were 27.0% and 89.4%, respectively. CONCLUSION : Use of the Roche Accuchek Active glucometer for the diagnosis of GDM cannot be recommended.en_ZA
dc.description.departmentInternal Medicineen_ZA
dc.description.departmentObstetrics and Gynaecologyen_ZA
dc.description.embargo2019-04-01
dc.description.librarianhj2018en_ZA
dc.description.sponsorshipThe Society for Endocrinology, Metabolism and Diabetes of South Africa, the South African Sugar Association and Roche.en_ZA
dc.description.urihttp://wileyonlinelibrary.com/journal/ijgoen_ZA
dc.identifier.citationAdam, S. and Rheeder, P. (2018), Evaluating the utility of a point-of-care glucometer for the diagnosis of gestational diabetes. International Journal of Gynecology and Obstetrics. 141(1): 91-96. doi:10.1002/ijgo.12399.en_ZA
dc.identifier.issn0020-7292 (print)
dc.identifier.issn1879-3479 (online)
dc.identifier.other10.1002/ijgo.12399
dc.identifier.urihttp://hdl.handle.net/2263/63991
dc.language.isoenen_ZA
dc.publisherWileyen_ZA
dc.rights© 2017 International Federation of Gynecology and Obstetrics. This is the pre-peer reviewed version of the following article : Evaluating the utility of a point-of-care glucometer for the diagnosis of gestational diabetes. International Journal of Gynecology and Obstetrics. 141(1): 91-96, 2018, doi : 10.1002/ijgo.12399. The definite version is available at : http://wileyonlinelibrary.com/journal/ijgo.en_ZA
dc.subjectPoint-of-care testingen_ZA
dc.subjectGlucometeren_ZA
dc.subjectAccuracyen_ZA
dc.subjectGestational diabetes mellitus (GDM)en_ZA
dc.subjectOral glucose tolerance test (OGTT)en_ZA
dc.subjectCoefficient of variance (CV)en_ZA
dc.subjectPoint-of-care (POC)en_ZA
dc.titleEvaluating the utility of a point-of-care glucometer for the diagnosis of gestational diabetesen_ZA
dc.typePostprint Articleen_ZA

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