New imaging tracers for the infected diabetic foot (nuclear and optical imaging)

dc.contributor.authorAnkrah, Alfred O.
dc.contributor.authorKlein, Hans C.
dc.contributor.authorElsinga, Philip H.
dc.date.accessioned2018-08-02T09:29:23Z
dc.date.issued2018
dc.description.abstractDiabetic Foot Infections (DFIs) are associated with increased morbidity, an economic burden on patients, their families and healthcare systems and increased mortality. Early diagnosis with prompt, appropriate and adequate treatment of the infected diabetic foot is crucial. The determination of DFIs, however, may be quite perplexing and invasive. Imaging is useful in the evaluation of certain cases of DFIs, especially in suspected instances with no overt clinical features, or in the diagnosis of osteomyelitis. Nuclear medicine imaging is currently used in the evaluation of DFIs; however, like all the imaging techniques now available, it has its limitations. Several radiopharmaceuticals presently available play useful roles in the management of DFIs, while new ones are being evaluated. Optical imaging techniques have recently demonstrated promising results in the evaluation of many infections including DFIs. Using the same molecule, a tracer can be labeled with a radioisotope or an optical imaging dye. This enables infections to be evaluated both pre- and intra-operatively when surgery is required in their management. In some cases, tracers have been simultaneously labeled with both a radioisotope and an optical imaging dye to produce a hybrid tracer. These new tracers potentially provide powerful and new opportunities in the management of DFIs. In this review, we briefly examine tracers that have been used in the evaluation of the infected diabetic foot. We then explore the potential of new imaging tracers currently under development for infection that may be useful in the management of DFIs.en_ZA
dc.description.departmentNuclear Medicineen_ZA
dc.description.embargo2019-02-01
dc.description.librarianhj2018en_ZA
dc.description.urihttps://benthamscience.com/journals/current-pharmaceutical-designen_ZA
dc.identifier.citationAnkrah, A.O., Klein, H.C. & Elsinga, P.H. 2018, 'New imaging tracers for the infected diabetic foot (nuclear and optical imaging)', Current Pharmaceutical Design, vol. 24, no. 12, pp. 1287-1303.en_ZA
dc.identifier.issn1381-6128 (print)
dc.identifier.issn1873-4286 (online)
dc.identifier.other10.2174/1381612824666180227094454
dc.identifier.urihttp://hdl.handle.net/2263/66060
dc.language.isoenen_ZA
dc.publisherBentham Scienceen_ZA
dc.rights© 2018 Bentham Science Publishersen_ZA
dc.subjectDiabetic foot infection (DFI)en_ZA
dc.subjectOptical imagingen_ZA
dc.subjectRadiopharmaceuticalsen_ZA
dc.subjectNuclear medicineen_ZA
dc.subjectOsteomyelitisen_ZA
dc.subjectBacteriaspecific imagingen_ZA
dc.subjectSPECT/CTen_ZA
dc.subjectPET/CTen_ZA
dc.subjectBone scintigraphyen_ZA
dc.subjectProbe-to-bone testen_ZA
dc.subjectTc-99m-Ciprofloxacinen_ZA
dc.subjectPET imagingen_ZA
dc.subjectBacterial infectionen_ZA
dc.subjectStaphylococcus aureusen_ZA
dc.subjectAntimicrobial peptide (AMP)en_ZA
dc.subjectQuality controlen_ZA
dc.subjectBiological evaluationen_ZA
dc.titleNew imaging tracers for the infected diabetic foot (nuclear and optical imaging)en_ZA
dc.typePostprint Articleen_ZA

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