Tick cell lines : tools for tick and tick-borne disease research
| dc.contributor.author | Bell-Sakyi, Lesley | |
| dc.contributor.author | Zweygarth, Erich | |
| dc.contributor.author | Blouin, Edmour F. | |
| dc.contributor.author | Gould, Ernest A. | |
| dc.contributor.author | Jongejan, Frans | |
| dc.date.accessioned | 2007-09-26T06:02:02Z | |
| dc.date.available | 2007-09-26T06:02:02Z | |
| dc.date.issued | 2007-09 | |
| dc.description.abstract | Over 40 cell lines are currently available from 13 ixodid and one argasid tick species. The successful isolation and propagation of several economically important tick-borne pathogens in tick cell lines has created a useful model to study interactions between tick cells and these viral and bacterial disease agents. Tick cell lines have already proved to be a useful tool in helping to define the complex nature of the host–vector–pathogen relationship. With the availability of genomics tools, tick cell lines will become increasingly important as a complement to tick and tick-borne disease research in vivo once genetic transformation and gene silencing using RNA interference become routine. | en |
| dc.description.sponsorship | Writing of this article has been facilitated through The Integrated Consortium on Ticks and Tick-borne Diseases (ICTTD-3) financed by the International Cooperation Programme of the European Union through Coordination Action Project no. 510561. Current research on tick cell lines (L.B-S.) is supported by the Wellcome Trust project 0757990 ‘Adapting recombinant anti-tick vaccines to livestock in Africa’ and the European Union project INCO-CT-2005–003713 ’EPIGENEVAC’. Research on Anaplasma sp. (Omatjenne) in tick cells (E.Z.) has been supported by the USAID Cooperative Development Research Program, Grant Agreement No. TA-MOU-01-C21–027. Research on A. marginale in tick cells (E.F.B.) has been supported by the USDA–NRI Program. E.A.G. is supported by the European Union 6th Framework programme ‘VIZIER’. | en |
| dc.format.extent | 426513 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.citation | Bell-Sakyi, L, Zweygarth, E, Blouin, EF, Gould, EA & Jongejan, F 2007, ‘Tick-host-pathogen interactions in the post-genomic era’, Trends in Parasitology, vol. 23, no. 9, pp. 450-457 [http://www.sciencedirect.com/science/journal/14714922] | en |
| dc.identifier.issn | 1471-4922 | |
| dc.identifier.other | 10.1016/j.pt.2007.07.009 | |
| dc.identifier.uri | http://hdl.handle.net/2263/3557 | |
| dc.language.iso | en | en |
| dc.publisher | Elsevier | en |
| dc.rights | Elsevier | en |
| dc.subject | Tick-borne diseases | en |
| dc.subject | Ticks | en |
| dc.subject.lcsh | Tick-borne diseases -- Research | en |
| dc.subject.lcsh | Ticks as carriers of disease | en |
| dc.subject.lcsh | Ticks -- Research | en |
| dc.subject.lcsh | Host-parasite relationships | en |
| dc.title | Tick cell lines : tools for tick and tick-borne disease research | en |
| dc.type | Postprint Article | en |