Why does serum contain ferritin?
dc.contributor.author | Kell, Douglas B. | |
dc.contributor.author | Pretorius, Etheresia | |
dc.contributor.email | resia.pretorius@up.ac.za | en_ZA |
dc.date.accessioned | 2016-07-04T09:31:40Z | |
dc.date.available | 2016-07-04T09:31:40Z | |
dc.date.issued | 2015 | |
dc.description.abstract | In a recent article, Koperdanova and Cullis 1 rehearsed the various interpretations of raised serum ferritin levels. In fact the most interesting question 2 is why does ferritin appear in serum at all? All modern network models of iron metabolism (e.g. 3-7) have iron being passed from the gut to peripheral cells via blood (serum) bound to transferrin, a well-established iron-transporting molecule that is present in serum at ca 0.6-3.3 g.L-1 8. By contrast, ferritin is an intracellular iron storage compound 3 5 7; its normal range for serum is at levels 10,000-100,000 times lower than that for transferrin, being from very small levels to up to 300 μg.L-1 in men and slightly lower in women 2. | en_ZA |
dc.description.department | Physiology | en_ZA |
dc.description.librarian | am2016 | en_ZA |
dc.description.sponsorship | We thank the Biotechnology and Biological Sciences Research Council (grant BB/L025752/1) as well as the National Research Foundation (NRF) of South Africa for supporting this collaboration. | en_ZA |
dc.description.uri | http://www.bmj.com/thebmj | en_ZA |
dc.identifier.citation | Pretorius, E & Kell, DB 2015, 'Why does serum contain ferritin?', BMJ, vol. 351, h3692, pp. 1-3. | en_ZA |
dc.identifier.issn | 0959-8138 (print) | |
dc.identifier.issn | 1756-1833 (online) | |
dc.identifier.uri | http://hdl.handle.net/2263/53616 | |
dc.language.iso | en | en_ZA |
dc.publisher | BMJ Publishing Group | en_ZA |
dc.rights | This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license. | en_ZA |
dc.subject | Ferritin | en_ZA |
dc.subject | Apoptosis | en_ZA |
dc.subject | Iron dysregulation | en_ZA |
dc.subject | Inflammation | en_ZA |
dc.subject | Chronic diseases | en_ZA |
dc.subject | Atopobiosis | en_ZA |
dc.title | Why does serum contain ferritin? | en_ZA |
dc.type | Article | en_ZA |