Human leukocyte antigen diversity : a Southern African perspective
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Date
Authors
Tshabalala, Mqondisi
Mellet, Juanita
Pepper, Michael Sean
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi Publishing
Abstract
Despite the increasingly well-documented evidence of high genetic, ethnic, and linguistic diversity amongst African populations,
there is limited data on human leukocyte antigen (HLA) diversity in these populations. HLA is part of the host defensemechanism
mediated through antigen presentation to effector cells of the immune system. With the high disease burden in southern Africa,
HLA diversity data is increasingly important in the design of population-specific vaccines and the improvement of transplantation
therapeutic interventions. This review highlights the paucity of HLA diversity data amongst southern African populations and
defines a need for information of this kind.This information will support disease association studies, provide guidance in vaccine
design, and improve transplantation outcomes.
Description
Keywords
African populations, Immune system, Southern Africa, Human leukocyte antigen (HLA)
Sustainable Development Goals
Citation
Tshabalala, M, Mellet, J & Pepper, MS 2015, 'Human leukocyte antigen diversity : a Southern African perspective', Journal of Immunology Research, vol. 2015, art. no. 746151, pp. 1-11.