Nemaline myopathy in a six-month-old pomeranian dog

dc.contributor.authorBester, Elizabeth G.
dc.contributor.authorKitshoff, Adriaan Mynhardt
dc.contributor.authorBotha, W.J.
dc.contributor.authorVan Wilpe, Erna
dc.contributor.authorDu Plessis, Lizette
dc.contributor.authorWilliams, J.H. (June Heather)
dc.date.accessioned2023-08-24T04:32:22Z
dc.date.available2023-08-24T04:32:22Z
dc.date.issued2022
dc.description.abstractNemaline myopathy - a clinically and genetically complex heterogenous group of disorders - is described uncommonly in humans and rarely in animals, and is characterised by progressive muscle weakness. The diagnosis is confirmed by histological and/or ultrastructural identification of subsarcolemmal, thread-like, rod-shaped structures called nemaline rod bodies within more than 40% of skeletal muscle fibres. These rods contain the Z-line protein, α-actinin, that can be effectively stained in skeletal muscles using Gomori or Masson trichrome and negatively stained with periodic acid-Schiff. Similar rod-like bodies have been found in smaller numbers in dogs with endocrine disorders and occasionally in other conditions in humans. This report is of a six-month-old Pomeranian dog which had progressive exercise intolerance over a two-month period associated with severe disuse muscle atrophy of the thoracic limbs, as well as gradual pelvic limb weakness and regurgitation of food. Baseline diagnostics ruled out endocrinopathies and after histological and ultrastructural evaluation of thoracic limb muscles and nerve biopsies confirmed nemaline myopathy. The clinical course, diagnostic test results, ultrastructure of skeletal muscle and peripheral nerve, gross necropsy findings and histopathology using various stains are described and illustrated.en_US
dc.description.departmentAnatomy and Physiologyen_US
dc.description.departmentCompanion Animal Clinical Studiesen_US
dc.description.departmentParaclinical Sciencesen_US
dc.description.librarianam2023en_US
dc.description.urihttp://www.jsava.co.zaen_US
dc.identifier.citationBester, E.G., Kitshoff, A.M., Botha, W.J. et al. 2022, 'Nemaline myopathy in a six-month-old pomeranian dog', Journal of the South African Veterinary Association, vol. 93, no. 1, pp. 1-8. https://DOI.org/10.36303/JSAVA.2022.93.1.498.en_US
dc.identifier.issn1019-9128 (print)
dc.identifier.issn2224-9435 (online)
dc.identifier.other10.36303/JSAVA.2022.93.1.498
dc.identifier.urihttp://hdl.handle.net/2263/92016
dc.language.isoenen_US
dc.publisherMedpharm Publicationsen_US
dc.rights© 2022 The Author(s). Open Access article distributed under the terms of the Creative Commons License [CC BY-NC 3.0].en_US
dc.subjectCanineen_US
dc.subjectCongenitalen_US
dc.subjectGomori trichromeen_US
dc.subjectHistopathologyen_US
dc.subjectMasson trichromeen_US
dc.subjectNemaline myopathyen_US
dc.subjectUltrastructureen_US
dc.subjectDogs (Canis familiaris)en_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.titleNemaline myopathy in a six-month-old pomeranian dogen_US
dc.typeArticleen_US

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