The acidic tumour microenvironment : manipulating the immune response to elicit escape
| dc.contributor.author | Worsley, Catherine | |
| dc.contributor.author | Veale, Rob B. | |
| dc.contributor.author | Mayne, Elizabeth S. | |
| dc.contributor.email | u05116602@up.ac.za | en_US |
| dc.date.accessioned | 2023-09-06T13:18:24Z | |
| dc.date.available | 2023-09-06T13:18:24Z | |
| dc.date.issued | 2022-05 | |
| dc.description.abstract | The success of cancer treatment relies on the composition of the tumour microenvironment which is comprised of tumour cells, blood vessels, stromal cells, immune cells, and extracellular matrix components. Barriers to effective cancer treatment need to be overcome, and the acidic microenvironment of the tumour provides a key target for treatment. This review intends to provide an overview of the effects that low extracellular pH has on components of the tumour microenvironment and how they contribute to immune escape. Further, potential therapeutic targets will be discussed. | en_US |
| dc.description.department | Immunology | en_US |
| dc.description.librarian | hj2023 | en_US |
| dc.description.sponsorship | The National Research Foundation (NRF) Thuthuka program. | en_US |
| dc.description.uri | http://www.elsevier.com/locate/humimm | en_US |
| dc.identifier.citation | Worsley, C.M., Veale, R.B. & Mayne, E.S. 2022, 'The acidic tumour microenvironment: Manipulating the immune response to elicit escape', Human Immunology, vol. 83, no. 5, pp. 399-408, doi : 10.1016/j.humimm.2022.01.014. | en_US |
| dc.identifier.issn | 0198-8859 | |
| dc.identifier.other | 10.1016/j.humimm.2022.01.014 | |
| dc.identifier.uri | http://hdl.handle.net/2263/92233 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.rights | © 2022 American Society for Histocompatibility and Immunogenetics. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Human Immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Human Immunology, vol. 83, no. 5, pp. 399-408, 2022, doi : 10.1016/j.humimm.2022.01.014. | en_US |
| dc.subject | Tumour microenvironment (TME) | en_US |
| dc.subject | Acidosis | en_US |
| dc.subject | Tolerance | en_US |
| dc.subject | Immune escape | en_US |
| dc.subject | T cells | en_US |
| dc.subject | SDG-03: Good health and well-being | en_US |
| dc.title | The acidic tumour microenvironment : manipulating the immune response to elicit escape | en_US |
| dc.type | Postprint Article | en_US |