Identification of genuine/authentic avian leptin : some answers and more questions

dc.contributor.authorMillar, Robert P.
dc.date.accessioned2014-12-10T07:32:52Z
dc.date.available2014-12-10T07:32:52Z
dc.date.issued2014-09
dc.description.abstractThe dogmatic adherence to “what is good for the goose is good for the gander” appears to pervade avian endocrinology research when it comes to vertebrate evolution of hormones and their physiological roles in birds. There appears to be a general acceptance that specific hormones, their cognate receptors, and their regulatory functions identified in other vertebrates should be present and serve the same function in birds. This has been largely the case for leptin (LEP) originally identified in mammals (1– 5), which has been vigorously sought for more than a decade in birds (6 –10), and also more recently for kisspeptin (11, 12). But should we expect to find the same hormones and functions in birds as occurs in other vertebrates? In order for early reptilian bird ancestors to take to the air, phenomenal evolutionary changes in their physiology were required and presumably drove changes in the use of existing hormones and cognate receptors, their modification, or their abandonment. Yet many scientists take the view that major physiological systems present in tetrapods and fish should be present in birds and serve the same function and use of the same hormone/receptor regulators.en_ZA
dc.description.librarianam2014en_ZA
dc.description.sponsorshipGrants from the National Research Foundation and Medical Research Council of South Africa, and the Universities of Pretoria and Cape Town.en_ZA
dc.description.urihttp://press.endocrine.org/journal/endoen_ZA
dc.identifier.citationMillar, RP 2014, 'Identification of genuine/authentic avian leptin : some answers and more questions', Endocrinology. vol. 155, no. 9, pp. 3203-3205.en_ZA
dc.identifier.issn0013-7227 (print)
dc.identifier.issn1945-7170 (online)
dc.identifier.other10.1210/en.2014-1563
dc.identifier.urihttp://hdl.handle.net/2263/42920
dc.language.isoenen_ZA
dc.rights© 2014 by the Endocrine Societyen_ZA
dc.subjectAuthentic avian leptinen_ZA
dc.subjectLeptin (LEP)en_ZA
dc.subjectLEP receptor (LEPR)en_ZA
dc.titleIdentification of genuine/authentic avian leptin : some answers and more questionsen_ZA
dc.typeArticleen_ZA

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