UPSpace will be temporarily unavailable tonight from 19:00 to 23:00 (South African Time) due to scheduled maintenance. We apologise for any inconvenience this may cause and appreciate your understanding
 

The serum and fecal metabolomic profiles of growing kittens treated with amoxicillin/clavulanic acid or doxycycline

dc.contributor.authorStavroulaki, Evangelia M.
dc.contributor.authorSuchodols, Jan S.
dc.contributor.authorPilla, Rachel
dc.contributor.authorFosgate, Geoffrey Theodore
dc.contributor.authorSung, Chi-Hsuan
dc.contributor.authorLidbury, Jonathan
dc.contributor.authorSteiner, Jörg M.
dc.contributor.authorXenoulis, Panagiotis G.
dc.date.accessioned2022-07-14T06:50:09Z
dc.date.available2022-07-14T06:50:09Z
dc.date.issued2022-01
dc.descriptionSUPPLEMENTARY MATERIALS : TABLE S1: List of raw metabolites identified in serum samples by untargeted metabolomics. TABLE S2: List of metabolites identified in serum samples by untargeted metabolomics. Mean and standard deviation by group and time point. TABLE S3: List of raw metabolites identified in fecal samples by targeted metabolomics. TABLE S4: List of metabolites identified in fecal samples by targeted metabolomics. Mean and standard deviation by group and time point.en_US
dc.description.abstractThe long-term impact of antibiotics on the serum and fecal metabolome of kittens has not yet been investigated. Therefore, the objective of this study was to evaluate the serum and fecal metabolome of kittens with an upper respiratory tract infection (URTI) before, during, and after antibiotic treatment and compare it with that of healthy control cats. Thirty 2-month-old cats with a URTI were randomly assigned to receive either amoxicillin/clavulanic acid for 20 days or doxycycline for 28 days, and 15 cats of similar age were enrolled as controls. Fecal samples were collected on days 0, 20/28, 60, 120, and 300, while serum was collected on days 0, 20/28, and 300. Untargeted and targeted metabolomic analyses were performed on both serum and fecal samples. Seven metabolites differed significantly in antibiotic-treated cats compared to controls on day 20/28, with two differing on day 60, and two on day 120. Alterations in the pattern of serum amino acids, antioxidants, purines, and pyrimidines, as well as fecal bile acids, sterols, and fatty acids, were observed in antibiotic-treated groups that were not observed in control cats. However, the alterations caused by either amoxicillin/clavulanic acid or doxycycline of the fecal and serum metabolome were only temporary and were resolved by 10 months after their withdrawal.en_US
dc.description.departmentProduction Animal Studiesen_US
dc.description.sponsorshipWinn Feline Foundation, Miller Trust Award, and the Operational Program “Human Resources Development, Education and Life Lifelong Learning”en_US
dc.description.urihttp://www.mdpi.com/journal/animalsen_US
dc.identifier.citationStavroulaki, E.M.; Suchodolski, J.S.; Pilla, R.; Fosgate, G.T.; Sung, C.-H.; Lidbury, J.; Steiner, J.M.; Xenoulis, P.G. The Serum and Fecal Metabolomic Profiles of Growing Kittens Treated with Amoxicillin/Clavulanic Acid or Doxycycline. Animals 2022, 12, 330. https://doi.org/10.3390/ani12030330.en_US
dc.identifier.issn2076-2615 (online)
dc.identifier.other10.3390/ani12030330
dc.identifier.urihttps://repository.up.ac.za/handle/2263/86159
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licenseen_US
dc.subjectAntibioticsen_US
dc.subjectMetabolomic profileen_US
dc.subjectCatsen_US
dc.titleThe serum and fecal metabolomic profiles of growing kittens treated with amoxicillin/clavulanic acid or doxycyclineen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 5 of 5
Loading...
Thumbnail Image
Name:
Stavroulaki_Serum_2022.pdf
Size:
2.3 MB
Format:
Adobe Portable Document Format
Description:
Loading...
Thumbnail Image
Name:
Stavroulaki_SerumTabS1_2022.xlsx
Size:
995.3 KB
Format:
Microsoft Excel XML
Description:
Table S1
Loading...
Thumbnail Image
Name:
Stavroulaki_SerumTabS1_2022.xlsx
Size:
51.94 KB
Format:
Microsoft Excel XML
Description:
Table S2
Loading...
Thumbnail Image
Name:
Stavroulaki_SerumTabS3_2022.xlsx
Size:
179.09 KB
Format:
Microsoft Excel XML
Description:
Table S3
Loading...
Thumbnail Image
Name:
Stavroulaki_SerumTabS4_2022.xlsx
Size:
26.58 KB
Format:
Microsoft Excel XML
Description:
Table S4

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description: