Dominant genetic aberrations and coexistent EBV infection in HIV-related oral plasmablastic lymphomas

dc.contributor.authorBoy, Sonja Catharina
dc.contributor.authorVan Heerden, Marlene B.
dc.contributor.authorBabb, Chantal
dc.contributor.authorVan Heerden, Willem Francois Petrus
dc.contributor.authorPascale, Willem
dc.contributor.emailsonja.boy@up.ac.zaen_US
dc.date.accessioned2012-09-19T08:40:41Z
dc.date.available2012-09-19T08:40:41Z
dc.date.issued2011-09
dc.description.abstractWe present common cytogenetic features in the largest cohort of plasmablastic lymphoma (PBL) of the oral cavity published to date. This cohort included 45 patients, 32 of whom had a known HIV status, of which 31 were HIV positive. Ninety eight per cent of all PBL cases were known to be EBV positive. In line with previous studies, we found that rearrangements of the MYC gene was the most common genetic abnormality seen in 60% of cases with the immunoglobulin heavy chain (IGH) locus as a partner in 51% of cases. Additional complex genetic aberrations were frequent, in particular, an increased copy number of the CCND1 gene was seen in 41% of cases with true amplification of CCND1 in 15% of cases. Aneuploidy was also observed for the BCL6 gene in 28% of cases. Interestingly, rearrangements of both IGH genes were detected in 16% of cases with t(14;18) and t(11;14) respectively involved in conjunction with a t(8;14) in two cases. These bi-allelic IGH rearrangements have not been described before in oral PBL. Our results reinforce the notion that EBV infection and MYC rearrangements are important events in the pathogenesis of oral PBL. The genetic diversity and complexity observed in these cases, underlines the importance to genetically characterise PBL patients at presentation as this may inform the choice of more effective treatment modalities.en_US
dc.description.sponsorshipGrants from the South African Dental Association, National Research Foundation and National Health Laboratory Services Research Trust, South Africa.en_US
dc.description.urihttp://www.elsevier.com/locate/oraloncologyen_US
dc.identifier.citationSonja C. Boy, Marlene B. van Heerden, Chantal Babb, Willie F. van Heerden & Pascale Willem, Dominant genetic aberrations and coexistent EBV infection in HIV -related oral plasmablastic lymphomas, Oral Oncology, vol. 47, no. 9, pp. 883-887 (2011), doi: 10.1016/j.oraloncology.2011.06.506.en_US
dc.identifier.issn1368-8375 (print)
dc.identifier.issn1879-0593 (online)
dc.identifier.other10.1016/j.oraloncology.2011.06.506
dc.identifier.urihttp://hdl.handle.net/2263/19841
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2011 Elsevier. All rights reserved. Notice: this is the author's version of work that was accepted for publication in Oral Oncology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Oral Oncology, vol 47, Issue 9, September 2011, doi: 10.1016/j.oraloncology.2011.06.506.en_US
dc.subjectOral mucosaen_US
dc.subjectHIVen_US
dc.subjectMYCen_US
dc.subjectCCND1en_US
dc.subjectBCL6en_US
dc.subjectImmunoglobulin heavy chain (IGH)en_US
dc.subjectPlasmablastic lymphoma (PBL)en_US
dc.subjectEpstein Barr virus (EBV)en_US
dc.subject.lcshMouth -- Cancer -- Diagnosis -- South Africaen
dc.subject.lcshHIV infections -- Complications -- South Africaen
dc.subject.lcshImmunosuppression -- South Africaen
dc.titleDominant genetic aberrations and coexistent EBV infection in HIV-related oral plasmablastic lymphomasen_US
dc.typePostprint Articleen_US

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