Oxygen management during cardiopulmonary bypass : a single-center, 8-year retrospective cohort study

dc.contributor.authorGrocott, Bronwen B.
dc.contributor.authorKashani, Hessam H.
dc.contributor.authorMaakamedi, Hendrick
dc.contributor.authorDutta, Vikas
dc.contributor.authorHiebert, Brett
dc.contributor.authorRakar, Martin
dc.contributor.authorGrocott, Hilary P.
dc.date.accessioned2021-07-28T12:42:43Z
dc.date.issued2021-01
dc.description.abstractOBJECTIVE : To characterize the institutional oxygen management practices during cardiopulmonary bypass (CPB) in patients undergoing cardiac surgery, including any potential changes during an 8-year study period. DESIGN : A retrospective cohort study. SETTING : A tertiary care cardiac surgical program. PARTICIPANTS : Patients who underwent cardiac surgery involving CPB, with or without hypothermic circulatory arrest (HCA), between January 1, 2010, and December 31, 2017. MEASUREMENTS AND MAIN RESULTS : In addition to baseline patient characteristics, the authors recorded the partial pressures of arterial oxygen (Pa o 2 ), fraction of inspired oxygen, and mixed venous oxygen saturation during CPB of 696 randomly selected patients during an 8-year study period. The overall mean Pa o 2 was 255 ± 48 mmHg, without any significant change during the 8-year study period (p = 0 . 30). The mean Pa o 2 of HCA patients was significantly higher than in patients without HCA (327 ± 93 mmHg v 252 ± 45 mmHg, respectively; p < 0 . 001). CONCLUSIONS : The current approach to oxygen management during CPB at the authors’ institution is within the range of hyperoxemic levels, and these practices have not changed over time. The impact of these practices on patients’ outcomes is not fully understood, and additional studies are needed to establish firm evidence to guide optimal oxygen management practice during CPB.en_ZA
dc.description.departmentAnaesthesiologyen_ZA
dc.description.embargo2022-01-01
dc.description.librarianhj2021en_ZA
dc.description.sponsorshipThe University of Manitoba Department of Anesthesiology, Perioperative and Pain Medicineen_ZA
dc.description.urihttps://www.elsevier.com/locate/jbusresen_ZA
dc.identifier.citationGrocott, B.B., Kashani, H.H., Maakamedi, H. et al. 2021, 'Oxygen management during cardiopulmonary bypass: a single-center, 8-year retrospective cohort study', Journal of Cardiothoracic and Vascular Anesthesia, vol. 35, no. 1, pp. 100-105.en_ZA
dc.identifier.issn1053-0770
dc.identifier.other10.1053/j.jvca.2020.08.029
dc.identifier.urihttp://hdl.handle.net/2263/81037
dc.language.isoenen_ZA
dc.publisherElsevieren_ZA
dc.rights© 2020 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Journal of Cardiothoracic and Vascular Anesthesia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Journal of Cardiothoracic and Vascular Anesthesia, vol. 35, no. 1, pp. 100-105, 2021. doi : 10.1053/j.jvca.2020.08.029.en_ZA
dc.subjectCardiopulmonary bypass (CPB)en_ZA
dc.subjectHyperoxiaen_ZA
dc.subjectOxygen managementen_ZA
dc.subjectCardiac surgeryen_ZA
dc.subject.otherHealth sciences articles SDG-03
dc.subject.otherSDG-03: Good health and well-being
dc.subject.otherHealth sciences articles SDG-17
dc.subject.otherSDG-17: Partnerships for the goals
dc.titleOxygen management during cardiopulmonary bypass : a single-center, 8-year retrospective cohort studyen_ZA
dc.typePostprint Articleen_ZA

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Grocott_Oxygen_2021.pdf
Size:
226.53 KB
Format:
Adobe Portable Document Format
Description:
Postprint Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description: