HLA-B27 and an electrocardiographic peculiarity

dc.contributor.authorKer, James A.
dc.date.accessioned2012-05-23T08:27:06Z
dc.date.available2012-05-23T08:27:06Z
dc.date.issued2011-09-06
dc.description.abstractINTRODUCTION: An increased cardiovascular mortality has been described in patients with spondyloarthropathies due to HLA-B27. Numerous cardiovascular afflictions are currently known to be associated with HLA-B27. These include aortic root dilation, aortic regurgitation, mitral regurgitation, myocarditis, heart failure, pericarditis, pericardial effusion, atrioventricular conduction block and more recently, the presence of J-waves. MATERIALS AND METHODS: 48 HLA-B27 positive patients (23 men and 25 women) were included in this observational study. A 12-lead electrocardiogram and a signal-averaged electrocardiogram was recorded in every patient in order to detect any possible J-waves and ventricular late potentials respectively. RESULTS: 27 out of these 48 patients demonstrated a visible J-wave in the inferolateral leads. It was revealed that there is a likelihood ratio of 11.386 (p=0.00074) to demonstrate a visible J-wave if the duration of low-amplitude signals is less than 30 ms. CONCLUSION: HLA-B27 positive patients has a high incidence of inferolateral cardiac J-waves. There is a high probability of demonstrating such a J-wave on the 12-lead electrocardiogram if the duration of ventricular late potentials is less than 30 ms. The possible mechanisms of this electrocardiographic paradox is discussed.en_US
dc.description.urihttp://www.la-press.comen_US
dc.identifier.citationKer J (2011) HLA-B27 and an Electrocardiographic Peculiarity. J Clinic Experiment Cardiol 2:149. DOI: 10.4172/2155-9880.1000149en_US
dc.identifier.issn1179-5468
dc.identifier.other10.4172/2155-9880.1000149
dc.identifier.urihttp://hdl.handle.net/2263/18832
dc.language.isoenen_US
dc.rights© 2011 Ker J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectHLA-B27en_US
dc.subjectVentricularen_US
dc.subjectLate potentialsen_US
dc.subjectJ-waveen_US
dc.titleHLA-B27 and an electrocardiographic peculiarityen_US
dc.typeArticleen_US

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