Investigation of Brucella melitensis in sable antelope (Hippotragus niger) in South Africa

dc.contributor.authorGlover, Barbara
dc.contributor.authorMacfarlane, Malcolm
dc.contributor.authorBengis, Roy
dc.contributor.authorO’Dell, Jacques
dc.contributor.authorVan Heerden, Henriette
dc.contributor.authorAbernethy, D.A. (Darrell)
dc.contributor.emailhenriette.vanheerden@up.ac.zaen_ZA
dc.date.accessioned2021-07-05T08:40:24Z
dc.date.available2021-07-05T08:40:24Z
dc.date.issued2020-09-29
dc.descriptionSupplementary Data 1: Mitigation plan for Farm 1.en_ZA
dc.description.abstractIn this study, Brucella melitensis infection in sable antelope (Hippotragus niger) was investigated on two wildlife ranches in South Africa over a 12-year period in order to determine the origin of the outbreaks and the role of livestock in maintaining the disease. Retrospective data were obtained from farm records and interviews as well as samples tested from di erent disease scenarios and clinical settings. On one ranch, 10 of 74 sable tested seropositive for B. melitensis in 2004 but were certified clear of infection after no further brucellosis cases were detected following repeated serological tests and culling over a five-year period. Recrudescence occurred in 2013 (7 of 187 brucellosis positives) and in 2014 (one positive), with persistent, latent infection being the most reasonable explanation. In a second case study, linked to the first one through a common vendor, 15 of 80 sable tested positive in 2016, some five years after the acquisition of the animals from a putative source. Brucella melitensis biovar 1 and/or 3 were isolated from each outbreak on both ranches. Both outbreaks resulted in substantial losses for the owners, arising from testing and culling and significant resource expenditure by the state. The study identified the diagnostic challenges for identifying and resolving disease outbreaks in wildlife, the persistence of B. melitensis in sable, the risks associated with animal movements, and the need for a wildlife-sensitive disease control scheme. Although the actual source of infection could not be identified, the investigation points away from local livestock as a source of ongoing infection while the persistent infection is consistent with the disease circulating within small, ranched populations and being spread through the keeping and trading of high-value animals. The implications of the study findings to disease control in wildlife are discussed.en_ZA
dc.description.departmentCentre for Veterinary Wildlife Studiesen_ZA
dc.description.departmentParaclinical Sciencesen_ZA
dc.description.departmentProduction Animal Studiesen_ZA
dc.description.departmentVeterinary Tropical Diseasesen_ZA
dc.description.librarianam2021en_ZA
dc.description.sponsorshipThe ARC-Onderstepoort Veterinary Research (OVR); the Department of Agriculture, Land Reform and Rural Development; National Research Foundation (NRF) and the University of Pretoria.en_ZA
dc.description.urihttp://www.mdpi.com/journal/microorganismsen_ZA
dc.identifier.citationGlover, B., Macfarlane, M., Bengis, R. et al. 2020, 'Investigation of Brucella melitensis in sable antelope (Hippotragus niger) in South Africa', Microorganisms, vol. 8, art. 1494, pp. 1-12.en_ZA
dc.identifier.issn2076-2607 (online)
dc.identifier.other10.3390/microorganisms8101494
dc.identifier.urihttp://hdl.handle.net/2263/80716
dc.language.isoenen_ZA
dc.publisherMDPIen_ZA
dc.rights© 2020 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_ZA
dc.subjectBrucellosisen_ZA
dc.subjectBrucella melitensisen_ZA
dc.subjectWildlifeen_ZA
dc.subjectTracebacken_ZA
dc.subjectDescriptive epidemiologyen_ZA
dc.subjectDisease outbreaken_ZA
dc.subjectCase studiesen_ZA
dc.subjectSouth Africa (SA)en_ZA
dc.subjectSable antelope (Hippotragus niger)en_ZA
dc.subject.otherVeterinary science articles SDG-15en_ZA
dc.subject.otherSDG-15: Life on land
dc.titleInvestigation of Brucella melitensis in sable antelope (Hippotragus niger) in South Africaen_ZA
dc.typeArticleen_ZA

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