Effects of soy phytoestrogens and New Zealand functional foods on bone health

dc.contributor.authorKruger, Marlena C.
dc.contributor.authorTousen, Y.
dc.contributor.authorKatsumata, S.
dc.contributor.authorTadaishi, M.
dc.contributor.authorKasonga, Abe E.
dc.contributor.authorDeepak, Vishwa
dc.contributor.authorCoetzee, Magdalena
dc.contributor.authorIshimi, Y.
dc.date.accessioned2015-10-07T11:06:05Z
dc.date.available2015-10-07T11:06:05Z
dc.date.issued2015-05
dc.description.abstractNew Zealand is a rich source of food components that may have bioactivity on bone. Docosahexaenoic acid (DHA) from fish oil has been shown to maintain bone in ovariectomised (OVX) rats. Kiwifruit, a source of fibre and carotenoids may also affect bone via a prebiotic as well as direct cell based mechanisms. We aimed to 1) ascertain the effects of DHA on two cell models, including interactions with soy isoflavones; 2) and investigate the specific effects of carotenoids from kiwifruit as well as whole kiwifruit in cell based and rodent models as well as in a human study. RAW 264.7 mouse monocytes or mouse bone marrow were used to generate osteoclasts (OC). Cells were exposed to the agents between 5 and 21 days and formation and activity of OC measured, including molecular markers. DHA inhibited OC formation in both cell models, including expression of cathepsin K, NFATc1 as well as actin ring formation. Combination with isoflavones enhanced these effects. In OVX rats and mice fed with kiwifruit for 8 weeks, green kiwifruit reduced rate of bone loss after OVX, and in mice it reduced C-telopeptide of Type 1 collagen (CTX) levels and RANKL expression while in menopausal women, green kiwifruit affected blood lipids and bone markers positively.en_ZA
dc.description.librarianhb2015en_ZA
dc.description.urihttp://www.jsnfs.or.jp/english/english_jnsv.htmlen_ZA
dc.identifier.citationKruger, MC, Tousen, Y, Katsumata, S, Tadaishi, M, Kasonga, AE, Deepak, V, Coetzee, M & Ishimi, Y 2015, 'Effects of soy phytoestrogens and New Zealand functional foods on bone health', Journal of Nutritional Science and Vitaminology, vol. 61, pp. S142-S144.en_ZA
dc.identifier.issn0301-4800 (print)
dc.identifier.issn1881-7742 (online)
dc.identifier.urihttp://hdl.handle.net/2263/50175
dc.language.isoenen_ZA
dc.publisherCenter for Academic Publications Japanen_ZA
dc.rightsCenter for Academic Publications Japan.en_ZA
dc.subjectKiwifruiten_ZA
dc.subjectOmega 3 fatsen_ZA
dc.subjectOsteoclastsen_ZA
dc.subjectBoneen_ZA
dc.subjectSoy phytoestrogensen_ZA
dc.titleEffects of soy phytoestrogens and New Zealand functional foods on bone healthen_ZA
dc.typePostprint Articleen_ZA

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Kruger_Effects_2015.pdf
Size:
140.92 KB
Format:
Adobe Portable Document Format
Description:
Postprint Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: