SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma
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Date
Authors
Wibmer, Constantinos Kurt
Ayres, Frances
Hermanus, Tandile
Madzivhandila, Mashudu
Kgagudi, Prudence
Oosthuysen, Brent
Lambson, Bronwen E.
De Oliveira, Tulio
Vermeulen, Marion
Van der Berg, Karin
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Abstract
SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.
Description
Supplementary Information: Supplementary Figs. 1 and 2
Keywords
Infectious diseases, COVID-19 pandemic, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Sustainable Development Goals
Citation
Wibmer, C.K., Ayres, F., Hermanus, T. et al. SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma. Nature Medicine 27, 622–625 (2021). https://doi.org/10.1038/s41591-021-01285-x.