Antinociceptive effects of epidural magnesium sulphate alone and in combination with morphine in dogs

dc.contributor.authorBahrenberg, Anne
dc.contributor.authorDzikiti, Brighton T.
dc.contributor.authorFosgate, Geoffrey Theodore
dc.contributor.authorStegmann, George F.
dc.contributor.authorTacke, Sabine P.
dc.contributor.authorRioja-Garcia, Eva
dc.date.accessioned2015-11-25T06:05:09Z
dc.date.issued2015-05
dc.description.abstractOBJECTIVE : To compare the antinociceptive effects of magnesium sulphate (MgSO4) when administered epidurally alone and in combination with morphine. STUDY DESIGN : Experimental, randomized, ‘blinded’, crossover study. ANIMALS : Six healthy adult Beagle dogs. METHODS : Evaluated treatments were MgSO4 (2.5 mg kg 1) alone (Mg), morphine (0.1 mg kg 1) alone (Mo), MgSO4 in combination with morphine (Mm), and sterile water (0.115 mL kg 1; Co) that were injected in the lumbosacral epidural space using an epidural catheter. Antinociception was measured using the von Frey mechanical threshold device applied to the carpal pads, both sides of the thorax and metatarsi. Measurements were obtained at time points: before treatment (baseline) and 0.5, 1, 2, 4, 6, 12, 18 and 24 hours after the epidural injection. Sedation, behaviour score and presence of motor deficits were assessed. Data were analyzed using a linear mixed model and Bonferroni adjustments, with significance set at p < 0.05. RESULTS : There were significant effects of treatment and time in all regions. Overall threshold values in grammes force [median (interquartile range)] when stimulation regions were combined were significantly higher in Mg [164 (135–200)], Mo 156 (129–195)] and Mm [158 (131–192)] compared to Co [145 (120–179)]. Thresholds were significantly higher compared to Co in Mg, Mo and Mm at the thorax and metatarsi, but only in Mg and Mo at the carpal pads. No motor deficits were observed at any time point. Thresholds (combined regions) were increased from baseline at one or more time points with all treatments, including control. CONCLUSION AND CLINICAL RELEVANCE : Epidural MgSO4 produced an antinociceptive effect characterised by an increase in the mechanical thresholds of similar magnitude to that produced by epidural morphine, compared with the control group, without causing any motor deficits. No potentiation of morphine antinociception was observed. The onset and offset times of antinociception could not be clearly established. To what extent these results can be extrapolated to clinical cases requires further investigation.en_ZA
dc.description.embargo2016-05-31
dc.description.librarianhb2015en_ZA
dc.description.sponsorshipDepartment of Companion Animal Clinical Studies of the University of Pretoria and the University of Pretoria Research Fund.en_ZA
dc.description.urihttp://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1467-2995en_ZA
dc.identifier.citationBahrenberg, A, Dzikiti, BT, Fosgate, GT, Stegmann, FG, Tacke, SP & Rioja, E 2015, 'Antinociceptive effects of epidural magnesium sulphate alone and in combination with morphine in dogs', Veterinary Anaesthesia and Analgesia, vol. 42, no. 3, pp. 319-328.en_ZA
dc.identifier.issn1467-2987 (print)
dc.identifier.issn1467-2995 (online)
dc.identifier.other10.1111/vaa.12211
dc.identifier.other27967665100
dc.identifier.otherN-8696-2014
dc.identifier.other6603440077
dc.identifier.urihttp://hdl.handle.net/2263/50604
dc.language.isoenen_ZA
dc.publisherWileyen_ZA
dc.rights© 2014 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia. This is the pre-peer reviewed version of the following article :Antinociceptive effects of epidural magnesium sulphate alone and in combination with morphine in dogs, Veterinary Anaesthesia and Analgesia, vol. 42, no. 3, pp. 319-328, 2015. doi : 10.1111/vaa.12211. The definite version is available at : http://onlinelibrary.wiley.comjournal/10.1111/(ISSN)1467-2995.en_ZA
dc.subjectAnalgesiaen_ZA
dc.subjectCanineen_ZA
dc.subjectEpidural anaesthesiaen_ZA
dc.subjectMagnesium sulphateen_ZA
dc.subjectMechanical thresholden_ZA
dc.subjectNeuraxialen_ZA
dc.titleAntinociceptive effects of epidural magnesium sulphate alone and in combination with morphine in dogsen_ZA
dc.typePostprint Articleen_ZA

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Bahrenberg_Antinociceptive_2015.pdf
Size:
185.58 KB
Format:
Adobe Portable Document Format
Description:
Postprint Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: