The effects of repeated intravenous iohexol administration on renal function in healthy beagles - a preliminary report

dc.contributor.authorKirberger, Robert M.
dc.contributor.authorCassel, Nicolette
dc.contributor.authorCarstens, Ann
dc.contributor.authorGoddard, Amelia
dc.contributor.emailrobert.kirberger@up.ac.zaen
dc.date.accessioned2013-01-29T06:16:43Z
dc.date.available2013-01-29T06:16:43Z
dc.date.issued2012-08-14
dc.description.abstractBACKGROUND Contrast induced nephrotoxicity (CIN) is a well described syndrome in humans undergoing contrast medium examinations. To date CIN has received minimal attention in the veterinary literature despite increasing use of contrast medium examinations in computed tomographic studies. METHODS This prospective study evaluated the effect of 1290 mg/kg iohexol given intravenously to 5 normal beagle dogs in a divided dose at an interval of 6–8 weeks. Renal function was evaluated by means of scintigraphically determined glomerular filtration rate (GFR) and a variety of laboratory assays. RESULTS Only GFR showed a significant decrease (17%) after the second injection but not to a clinically or pathologically significant level. CONCLUSIONS No clinically significant effect of repeated contrast medium administration was determined in this limited study. However in dogs with reduced renal function the risk of CIN is likely to increase dramatically post contrast administration.en
dc.description.librarianam2013en
dc.description.librarianmn2013
dc.description.urihttp://www.actavetscand.com/content/54/1/47en
dc.identifier.citationKirberger, RM, Cassel, N, Carstens, A & Goddard, A 2012, 'The effects of repeated intravenous iohexol administration on renal function in healthy beagles - a preliminary report', Thyroid Research, vol. 54, no. 47, pp. 1-20.en
dc.identifier.issn1751-0147 (print)
dc.identifier.other10.1186/1751-0147-54-47
dc.identifier.other7004586182
dc.identifier.otherN-8699-2014
dc.identifier.urihttp://hdl.handle.net/2263/20895
dc.language.isoenen
dc.publisherBioMed Centralen
dc.rights© 2012 Kirberger et al. ; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution Licenseen
dc.subjectDogsen
dc.subjectContrast induced nephrotoxicityen
dc.subjectLohexolen
dc.subjectContrast induced nephrotoxicity (CIN)en
dc.subjectGlomerular filtration rate (GFR)en
dc.subjectComputed tomographyen
dc.subjectCT
dc.titleThe effects of repeated intravenous iohexol administration on renal function in healthy beagles - a preliminary reporten
dc.typeArticleen

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