Lymphopenia and IgG2 subclass deficiency in patients with severe COVID-19 pneumonia
dc.contributor.author | Taban, E.M. | |
dc.contributor.author | Tintinger, Gregory Ronald | |
dc.contributor.author | Joseph, Darren | |
dc.contributor.author | Gaylard. P. | |
dc.contributor.author | Richards, D. | |
dc.date.accessioned | 2022-01-28T09:29:37Z | |
dc.date.available | 2022-01-28T09:29:37Z | |
dc.date.issued | 2021-03-29 | |
dc.description.abstract | BACKGROUND : COVID-19 caused by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) manifests with a range of disease severities. A small proportion of COVID-19 patients are severely ill; however, a significant proportion of these patients are critically ill, and require admission and mechanical ventilation, which is associated with a high mortality. OBJECTIVE : To identify factors that may predispose patients with COVID-19 to severe disease that requires mechanical ventilation (MV). METHODS : We performed a retrospective audit of patients admitted with COVID-19 pneumonia to the intensive care unit (ICU) and medical wards to evaluate the potential associations between comorbid conditions, lymphopenia and IgG subclass deficiency with a need for MV. RESULTS : A total of 51 patients were included in the study. Almost half of the patients (47%; n=24) were documented to have IgG2 deficiency, 43% (n=22) had lymphopenia and 37% (n=19) had combined lymphopenia and IgG2 subclass deficiency. Of the 24 patients who required MV, 75% had IgG2 subclass deficiency, 73% had lymphopenia and 50% had both. The relative risk for requiring MV was 2.64, 3.38 and 2.81 for lymphopenia, IgG2 subclass deficiency and both, respectively. CONCLUSIONS : These findings suggest that lymphopenia, low IgG2 concentrations or the combination of both may be used to identify patients with severe COVID-19 that are at increased risk for MV. This may facilitate earlier identification of patients at high risk, who may benefit from more intensive therapy. | en_ZA |
dc.description.department | Internal Medicine | en_ZA |
dc.description.librarian | am2022 | en_ZA |
dc.description.uri | https://journals.co.za/journal/m.ajtccm | en_ZA |
dc.identifier.citation | Taban, E.M., Tintinger, G.R., Joseph, D. et al. 2021, 'Lymphopenia and IgG2 subclass deficiency in patients with severe COVID-19 pneumonia', African Journal of Thoracic and Critical Care Medicine, vol. 27, no. 2, pp. 1-6. | en_ZA |
dc.identifier.issn | 2617-0191 | |
dc.identifier.other | 10.7196/AJTCCM.2021.v27i2.134 | |
dc.identifier.uri | http://hdl.handle.net/2263/83506 | |
dc.language.iso | en | en_ZA |
dc.publisher | South African Medical Association NPC | en_ZA |
dc.rights | South African Medical Association NPC | en_ZA |
dc.subject | Patients | en_ZA |
dc.subject | COVID-19 pandemic | en_ZA |
dc.subject | Coronavirus disease 2019 (COVID-19) | en_ZA |
dc.subject | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) | en_ZA |
dc.subject | Intensive care unit (ICU) | en_ZA |
dc.subject | Mechanical ventilation (MV) | en_ZA |
dc.subject | Lymphopenia | en_ZA |
dc.subject | IgG2 concentrations | en_ZA |
dc.title | Lymphopenia and IgG2 subclass deficiency in patients with severe COVID-19 pneumonia | en_ZA |
dc.type | Article | en_ZA |