New syntheses of (±)-tashiromine and (±)-epitashiromine via enaminone intermediates

dc.contributor.authorRiley, Darren Lyall
dc.contributor.authorMichael, Joseph P.
dc.contributor.authorDe Koning, Charles B.
dc.contributor.emaildarren.riley@up.ac.zaen_ZA
dc.date.accessioned2017-01-27T06:02:23Z
dc.date.available2017-01-27T06:02:23Z
dc.date.issued2016-12-02
dc.descriptionSupporting Information File 1 Experimental procedures and copies of NMR spectra.en_ZA
dc.description.abstractThe syntheses of the naturally occurring indolizidine alkaloid (±)-tashiromine and its unnatural epimer (±)-epitashiromine are demonstrated through the use of enaminone chemistry. The impact of various electron-withdrawing substituents at the C-8 position of the indolizidine core on the preparation of the bicyclic system is described.en_ZA
dc.description.departmentChemistryen_ZA
dc.description.librarianam2017en_ZA
dc.description.sponsorshipThis work is based on research supported by the National Research Foundation of South Africa, Pretoria (grant numbers 85964 and 93447), and by the University of the Witwatersranden_ZA
dc.description.sponsorshipThe National Research Foundation of South Africa, Pretoria (grant numbers 85964 and 93447), and by the University of the Witwatersrand.en_ZA
dc.description.urihttp://www.sherpa.ac.uk/romeo/issn/1860-5397/en_ZA
dc.identifier.citationRiley, D.L., Michael, J.P. & De Koning, C.B. New syntheses of (±)-tashiromine and (±)-epitashiromine via enaminone intermediates. Beilstein Journal of Organic Chemistry. 2016, 12, 2609–2613. DOI: 10.3762/bjoc.12.256.en_ZA
dc.identifier.issn1860-5397
dc.identifier.other10.3762/bjoc.12.256
dc.identifier.urihttp://hdl.handle.net/2263/58659
dc.language.isoenen_ZA
dc.publisherBeilstein-Instituten_ZA
dc.rights© 2016 Riley et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0),.en_ZA
dc.subjectAlkaloiden_ZA
dc.subjectEnaminoneen_ZA
dc.subjectEpitashiromineen_ZA
dc.subjectIndolizidineen_ZA
dc.subjectTashiromineen_ZA
dc.titleNew syntheses of (±)-tashiromine and (±)-epitashiromine via enaminone intermediatesen_ZA
dc.typeArticleen_ZA

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