Comparison of three commercial molecular assays for detection of rifampin and isoniazid resistance among Mycobacterium tuberculosis isolates in a high-HIV-prevalence setting

dc.contributor.authorStrydom, Kathy-Anne
dc.contributor.authorIsmail, Farzana
dc.contributor.authorMatabane, M.M.Z.
dc.contributor.authorOnwuegbuna, O.
dc.contributor.authorOmar, Shaheed Vally
dc.contributor.authorIsmail, Nabila
dc.date.accessioned2015-12-04T05:18:33Z
dc.date.issued2015-09
dc.description.abstractIn a head to head comparison of the MTBDRplus Version 2.0 (Hain Lifescience), Xpert® MTB/RIF (Cepheid) and the Anyplex™ MTB/NTM (Seegene) assays we demonstrate equal sensitivity (59/61; 96.7%) and specificity (53/54; 98.1%) for detecting rifampicin resistance with further analysis of discordances. The Xpert does not detect Isoniazid resistance while Anyplex showed high false positivity.en_ZA
dc.description.embargo2016-03-31
dc.description.librarianhb2015en_ZA
dc.description.sponsorshipNational Health Laboratory Servicesen_ZA
dc.description.urihttp://jcm.asm.orgen_ZA
dc.identifier.citationStrydom, KA, Ismail, F, Matabane, MMZ, Onwuegbuna, O, Omar, SV & Ismail, N 2015, 'Comparison of three commercial molecular assays for detection of rifampin and isoniazid resistance among Mycobacterium tuberculosis isolates in a high-HIV-prevalence setting', Journal of Clinical Microbiology, vol. 53, no. 9, pp. 3032-3034.en_ZA
dc.identifier.issn0095-1137 (print)
dc.identifier.issn1098-660X (online)
dc.identifier.other10.1128/JCM.01691-15
dc.identifier.urihttp://hdl.handle.net/2263/51054
dc.language.isoenen_ZA
dc.publisherAmerican Society for Microbiologyen_ZA
dc.rights© 2015. American Society for Microbiology. All Rights Reserved.en_ZA
dc.subjectRifampicinen_ZA
dc.subjectIsoniaziden_ZA
dc.subjectMycobacterium tuberculosisen_ZA
dc.subjectHigh HIV prevalence settingen_ZA
dc.titleComparison of three commercial molecular assays for detection of rifampin and isoniazid resistance among Mycobacterium tuberculosis isolates in a high-HIV-prevalence settingen_ZA
dc.typePostprint Articleen_ZA

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Strydom_Comparison_2015.pdf
Size:
187.65 KB
Format:
Adobe Portable Document Format
Description:
Postprint Article
Download

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research Articles (Medical Microbiology)
Research Articles (University of Pretoria)
Simple item page