A study of the pharmacokinetics and thromboxane inhibitory activity of a single intramuscular dose of carprofen as a means to establish its potential use as an analgesic drug in white rhinoceros

dc.contributor.authorLeiberich, Marion
dc.contributor.authorKrebber, R.
dc.contributor.authorHewetson, Michael
dc.contributor.authorMarais, J.
dc.contributor.authorNaidoo, Vinny
dc.date.accessioned2018-07-27T05:56:42Z
dc.date.issued2018-08
dc.description.abstractThe alleviation of pain and prevention of suffering are key aspects of animal welfare. Unfortunately, analgesic drugs are not available for all species. White rhinoceros (Ceratotherium simum), representing one of such species, which survive poaching attempts inflicted with severe facial injuries and gunshot wounds, nonetheless require analgesic support. To improve treatment conditions, this study explored the use of carprofen for the treatment of pain and inflammation in white rhinoceros. The pharmacokinetics of 1 mg/kg intramuscular carprofen was evaluated in six healthy white rhinoceros. The half‐life of λz and mean residence time was 105.71 ± 15.67 and 155.01 ± 22.46 hr, respectively. The area under the curve and the maximum carprofen concentration were 904.61 ± 110.78 μg ml−1 hr−1 and 5.77 ± 0.63 μg/ml, respectively. Plasma TXB2 inhibition demonstrated anti‐inflammatory properties and indicated that carprofen may be effective for a minimum of 48 hr in most animals. With its long half‐life further indicating that a single dose could be effective for several days, we suggest that carprofen may be a useful drug for the treatment of white rhinoceros.en_ZA
dc.description.departmentCompanion Animal Clinical Studiesen_ZA
dc.description.departmentParaclinical Sciencesen_ZA
dc.description.embargo2019-08-01
dc.description.librarianhj2018en_ZA
dc.description.sponsorshipZoetis; South African Veterinary Association (SAVA); Bayer Animal Health; Deutscher Akademischer Austauschdienst; University of Pretoriaen_ZA
dc.description.urihttp://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2885en_ZA
dc.identifier.citationLeiberich, M., Krebber, R., Hewetson, M. et al. 2018, 'A study of the pharmacokinetics and thromboxane inhibitory activity of a single intramuscular dose of carprofen as a means to establish its potential use as an analgesic drug in white rhinoceros', Journal of Veterinary Pharmacology and Therapeutics, vol. 41, no. 4, pp. 605-613.en_ZA
dc.identifier.issn0140-7783 (print)
dc.identifier.issn1365-2885 (online)
dc.identifier.other10.1111/jvp.12508
dc.identifier.urihttp://hdl.handle.net/2263/66004
dc.language.isoenen_ZA
dc.publisherWileyen_ZA
dc.rights© John Wiley and Sons Ltd. This is the pre-peer reviewed version of the following article : 'A study of the pharmacokinetics and thromboxane inhibitory activity of a single intramuscular dose of carprofen as a means to establish its potential use as an analgesic drug in white rhinoceros', Journal of Veterinary Pharmacology and Therapeutics, vol. 41, no. 4, pp. 605-613, 2018, doi : 10.1111/jvp.12508. The definite version is available at : http://onlinelibrary.wiley.comjournal/10.1111/(ISSN)1365-2885.en_ZA
dc.subjectAnalgesiaen_ZA
dc.subjectCarprofenen_ZA
dc.subjectNSAIDen_ZA
dc.subjectPharmacokineticsen_ZA
dc.subjectWhite rhinoceros (Ceratotherium simum)en_ZA
dc.subjectSheepen_ZA
dc.subjectCalvesen_ZA
dc.subjectToleranceen_ZA
dc.subjectHorse (Equus caballus)en_ZA
dc.subjectDogs (Canis familiaris)en_ZA
dc.subjectEnrofloxacinen_ZA
dc.titleA study of the pharmacokinetics and thromboxane inhibitory activity of a single intramuscular dose of carprofen as a means to establish its potential use as an analgesic drug in white rhinocerosen_ZA
dc.typePostprint Articleen_ZA

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