Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy : a pilot study
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Date
Authors
Chaudhry, Mamoonah
Alessandrini, Marco
Rademan, Jacobus
Dodgen, Tyren Mark
Steffens, Francois E.
Van Zyl, Danie G.
Gaedigk, Andrea
Pepper, Michael Sean
Journal Title
Journal ISSN
Volume Title
Publisher
Future Medicine
Abstract
AIM : Therapy with low-dose amitriptyline is commonly used to treat painful diabetic peripheral neuropathy. There is a knowledge gap, however, regarding the role of variable CYP2D6-mediated drug metabolism and side effects (SEs). We aimed to generate pilot data to demonstrate that SEs are more frequent in patients with variant CYP2D6 alleles. METHOD : To that end, 31 randomly recruited participants were treated with low-dose amitriptyline for painful diabetic peripheral neuropathy and their CYP2D6 gene sequenced. RESULTS : Patients with predicted normal or ultra-rapid metabolizer phenotypes presented with less SEs compared with individuals with decreased CYP2D6 activity. CONCLUSION : Hence, CYP2D6 genotype contributes to treatment outcome and may be useful for guiding drug therapy. Future investigations in a larger patient population are planned to support these preliminary findings.
Description
Keywords
Activity score, Adverse drug reactions, Amitriptyline, CYP2D6, Diabetic neuropathy, Pharmacogenetics, Demethylation, Indomethacin, Management, Rats, Pain
Sustainable Development Goals
Citation
Chaudhry, M., Alessandrini, M., Rademan, J. et al. 2017, 'Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy : a pilot study ', Pharmacogenomics, vol. 18, no. 5, pp. 433-443.