Performance of diagnostic tests based on continuous bivariate markers

dc.contributor.authorSamawi, Hani
dc.contributor.authorChen, Ding-Geng (Din)
dc.contributor.authorYin, Jingjing
dc.contributor.authorAlsharman, Marwan
dc.date.accessioned2023-09-29T08:34:00Z
dc.date.issued2024
dc.description.abstractIn medical diagnostic research, it is customary to collect multiple continuous biomarker measures to improve the accuracy of diagnostic tests. A prevalent practice is to combine the measurements of these biomarkers into one single composite score. However, incorporating those biomarker measurements into a single score depends on the combination of methods and may lose vital information needed to make an effective and accurate decision. Furthermore, a diagnostic cut-off is required for such a combined score, and it is difficult to interpret in actual clinical practice. The paper extends the classical biomarkers’ accuracy and predictive values from univariate to bivariate markers. Also, we will develop a novel pseudo-measures system to maximize the vital information from multiple biomarkers. We specified these pseudo-and-or classifiers for the true positive rate, true negative rate, false-positive rate, and false-negative rate. We used them to redefine classical measures such as the Youden index, diagnostics odds ratio, likelihood ratios, and predictive values. We provide optimal cut-off point selection based on the modified Youden index with numerical illustrations and real data analysis for this paper's newly developed pseudo measures.en_US
dc.description.departmentStatisticsen_US
dc.description.embargo2022-10-26
dc.description.librarianhj2023en_US
dc.description.urihttps://www.tandfonline.com/loi/cjas20en_US
dc.identifier.citationHani Samawi, Ding-Geng Chen, Jingjing Yin & Marwan Alsharman (2024) Performance of diagnostic tests based on continuous bivariate markers, Journal of Applied Statistics, 51:3, 497-514, DOI: 10.1080/02664763.2022.2137478.en_US
dc.identifier.issn0266-4763 (print)
dc.identifier.issn1360-0532 (online)
dc.identifier.other10.1080/02664763.2022.2137478
dc.identifier.urihttp://hdl.handle.net/2263/92603
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.rights© 2022 Informa UK Limited, trading as Taylor & Francis Group. This is an electronic version of an article published in Journal of Applied Statistics, vol. 51, no. 3, pp. 497-514 , 2024. doi : 10.1080/02664763.2022.2137478. Journal of Applied Statistics is available online at : http://www.tandfonline.comloi/cjas20.en_US
dc.subjectPredictive valuesen_US
dc.subjectOdds ratioen_US
dc.subjectYouden indexen_US
dc.subjectLikelihood ratiosen_US
dc.subjectBivariate analysisen_US
dc.titlePerformance of diagnostic tests based on continuous bivariate markersen_US
dc.typePostprint Articleen_US

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