Quantification of HIV-1 viral load in the fluid of ranulas in load in the fluid of ranulas in HIV-positive patients
| dc.contributor.author | Syebele, Kabunda | |
| dc.contributor.author | Butow, Kurt-Wilhelm | |
| dc.contributor.author | Webber, Lynne M. | |
| dc.contributor.author | Manda, S.O.M. (Samuel) | |
| dc.contributor.email | kabunda.syebele@up.ac.za | en_US |
| dc.date.accessioned | 2013-10-30T06:13:06Z | |
| dc.date.available | 2013-10-30T06:13:06Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | OBJECTIVE. This study aimed to detect and quantify the HIV-1 viral load in ranula fluid of HIV-positive patients. STUDY DESIGN. Fourteen HIV-positive patients (13 not on highly active antiretroviral therapy) presenting with ranulas were prospectively evaluated. The viral load in the ranula fluid was quantified, and the results were correlated with CD4 cell count and viral load in the patient’s blood. The NucliSens EasyQ system (NucliSens Easymag; bioMérieux), which is based on nucleic acid sequence–based amplification and real-time detection using molecular beacons, was used to quantitate viral RNA in the fluid. RESULTS. Concentrations of HIV-1 RNA ranged from 25 to 1,600,000 copies/mL in the fluid. However, no significant statistical correlation could be established with either CD4 cell count or viral load in patients’ blood. CONCLUSIONS. Various concentrations of HIV-1 RNA were found in ranula fluid, which appears to serve as a viral reservoir in HIV-infected patients. | en_US |
| dc.description.librarian | hb2013 | en_US |
| dc.description.uri | http://www.sciencedirect.com/science/journal/10792104/111 | en_US |
| dc.identifier.citation | Syebele, K , Bütow, KW, Webber, L & Manda, SO 2011, 'Quantification of HIV-1 viral load in the fluid of ranulas in load in the fluid of ranulas in HIV-positive patients', Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, vol. 111, no. 6, pp.715-719. | en_US |
| dc.identifier.issn | 1079-2104 (print) | |
| dc.identifier.issn | 1528-395X (online) | |
| dc.identifier.other | 10.1016/j.tripleo.2011.01.038 | |
| dc.identifier.uri | http://hdl.handle.net/2263/32212 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.rights | © 2011 Published by Mosby, Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology and Endodontology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology and Endodontology, vol. 111, no. 6, 2011, doi : 10.1016/j.tripleo.2011.01.038 | en_US |
| dc.subject | Quantification of HIV-1 viral load | en_US |
| dc.subject | Fluid of ranulas | en_US |
| dc.subject | HIV-positive patients | en_US |
| dc.title | Quantification of HIV-1 viral load in the fluid of ranulas in load in the fluid of ranulas in HIV-positive patients | en_US |
| dc.type | Postprint Article | en_US |