Evaluation of taxonomic characteristics of Matlo and Phala bat rabies-related lyssaviruses identified in South Africa

dc.contributor.authorViljoen, Natalie
dc.contributor.authorWeyer, Jacqueline
dc.contributor.authorCoertse, Jessica
dc.contributor.authorMarkotter, Wanda
dc.contributor.emailwanda.markotter@up.ac.zaen_US
dc.date.accessioned2023-11-30T11:09:27Z
dc.date.available2023-11-30T11:09:27Z
dc.date.issued2023-10-04
dc.descriptionSUPPLEMENTARY TABLES : TABLE S1. Percentage nucleotide and amino acid identity withMBLV; TABLE S2. Percentage nucleotide and amino acid identity with PBLV; TABLE S3. Summary of pathogenic determinants in lyssaviruses; TABLE S4. Summary of amino acid changes in antigenic regions on the G protein for lyssaviruses.en_US
dc.descriptionDATA AVAILABILITY STATEMENT : All relevant data are included within the manuscript and its Supplementary Materials.en_US
dc.description.abstractWe report the genetic characterization of two potentially novel rabies-related lyssaviruses identified from bats in Limpopo province, South Africa. Matlo bat lyssavirus (MBLV) was identified in two Miniopterus natalensis (Natal long-fingered) bats in 2015 and 2016, and Phala bat lyssavirus (PBLV) was identified in a Nycticeinops schlieffeni (Schlieffen’s) bat in 2021. The distribution of both of these bat species is largely confined to parts of Africa, with limited reports from the Arabian Peninsula. MBLV and PBLV were demonstrated to group with the unassigned and phylogroup I lyssaviruses, respectively. MBLV was most closely related to Lyssavirus caucasicus (WCBV), whereas PBLV was most closely related to Lyssavirus formosa (TWBLV-1) and Taiwan bat lyssavirus 2 (TWBLV-2), based on analysis of the N and G genes, the concatenated N + P +M+ G + L coding sequence, and the complete genome sequence. Based on our analysis, MBLV and WCBV appeared to constitute a phylogroup separate from Lyssavirus lleida (LLEBV) and Lyssavirus ikoma (IKOV). Analysis of the antigenic sites suggests that PBLV will likely be serologically distinguishable from established lyssaviruses in virusneutralization tests, whereas MBLV appeared to be antigenically highly similar to WCBV. Taken together, the findings suggested that, while PBLV is likely a new lyssavirus species, MBLV is likely related to WCBV.en_US
dc.description.departmentMedical Virologyen_US
dc.description.librarianam2023en_US
dc.description.sdgSDG-03:Good heatlh and well-beingen_US
dc.description.sponsorshipThe South African Research Chair Initiative of the Department of Science and Innovation and administered by the National Research Foundation (NRF) of South Africa and postdoctoral fellowship funding from the University of Pretoria (UP) under the UP Co-Funding Postdoctoral Fellowship Programme.en_US
dc.description.urihttps://www.mdpi.com/journal/virusesen_US
dc.identifier.citationViljoen, N.; Weyer, J.; Coertse, J.; Markotter, W. Evaluation of Taxonomic Characteristics of Matlo and Phala Bat Rabies-Related Lyssaviruses Identified in South Africa. Viruses 2023, 15, 2047. https://DOI.org/10.3390/v15102047.en_US
dc.identifier.issn1999-4915 (online)
dc.identifier.other10.3390/v15102047
dc.identifier.urihttp://hdl.handle.net/2263/93565
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rights© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_US
dc.subjectLyssavirusesen_US
dc.subjectRabiesen_US
dc.subjectSurveillanceen_US
dc.subjectMolecular characterizationen_US
dc.subjectSouth Africa (SA)en_US
dc.subjectBatsen_US
dc.subjectMatlo bat lyssavirus (MBLV)en_US
dc.subjectPhala bat lyssavirus (PBLV)en_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.titleEvaluation of taxonomic characteristics of Matlo and Phala bat rabies-related lyssaviruses identified in South Africaen_US
dc.typeArticleen_US

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