Serum anti-Müllerian hormone dynamics in mares following immunocontraception with anti-zona pellucida or -GnRH vaccines

dc.contributor.authorJoone, C.J. (Carolynne)
dc.contributor.authorSchulman, M.L. (Martin)
dc.contributor.authorFosgate, Geoffrey Theodore
dc.contributor.authorClaes, A.N.J.
dc.contributor.authorGupta, S.K.
dc.contributor.authorBotha, A.E. (Alma)
dc.contributor.authorHuman, Anne-Marie
dc.contributor.authorBertschinger, Hendrik Jan
dc.date.accessioned2017-11-22T05:18:30Z
dc.date.issued2018-01
dc.description.abstractCirculating anti-Müllerian hormone concentration (AMH) is positively correlated to the number of small growing follicles in the mare and may reflect ovarian function. Dynamics of AMH during immunocontraception have not previously been investigated. This study aimed to compare serum AMH in mares following treatment with native porcine zona pellucida (pZP), recombinant pZP3 and pZP4 (reZP) or gonadotrophin releasing hormone (GnRH) vaccines, and saline-treated controls. Stored sera collected during two previous studies examining ovarian activity in mares during zona pellucida (ZP) or GnRH immunocontraception were analysed for serum AMH. Data were compared among treatment groups using mixed-effects linear regression and one-way ANOVA with post hoc testing. Correlations between AMH and previously reported clinical variables were estimated using Spearman's rho. Mares immunized against GnRH showed variable but detectable AMH throughout successive breeding and non-breeding seasons that were not significantly different to unvaccinated control mares. Mares treated with pZP demonstrated marked, reversible suppression of AMH. Mares immunized using reZP showed an intermediate effect. In the ZP study, AMH was positively correlated to serum progesterone concentrations, mean ovarian volumes and antral follicle counts, whereas no correlations between AMH and serum progesterone concentrations, mean ovarian volumes, or the presence of one or more follicles ≥20 mm in diameter were detected in the GnRH study. In conclusion, marked suppression of AMH during pZP immunocontraception, but not during GnRH immunocontraception, suggested enhanced suppression of ovarian follicular development and, or follicular function during pZP immunocontraception. Serum AMH concentrations may provide a novel tool for the assessment of ovarian function during ZP-based immunocontraception.en_ZA
dc.description.departmentProduction Animal Studiesen_ZA
dc.description.embargo2019-01-15
dc.description.librarianhj2017en_ZA
dc.description.sponsorshipThe Technology Innovation Agency, Pretoria, South Africa (TAHC12 - 00042).en_ZA
dc.description.urihttp://www.theriojournal.comen_ZA
dc.identifier.citationJoonè, C.J., Schulman, M.L., Fosgate, G.T. ... et al. 2018, 'Serum anti-Müllerian hormone dynamics in mares following immunocontraception with anti-zona pellucida or -GnRH vaccines', Theriogenology, vol. 106, pp. 214-220.en_ZA
dc.identifier.issn0093-691X (print)
dc.identifier.issn1879-3231 (online)
dc.identifier.other10.1016/j.theriogenology.2017.10.004
dc.identifier.urihttp://hdl.handle.net/2263/63255
dc.language.isoenen_ZA
dc.publisherElsevieren_ZA
dc.rights© 2017 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Theriogenology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Theriogenology, vol. 106, pp. 214-220, 2018. doi : 10.1016/j.theriogenology.2017.10.004.en_ZA
dc.subjectAnti-Müllerian hormone concentration (AMH)en_ZA
dc.subjectGonadotrophin releasing hormone (GnRH)en_ZA
dc.subjectPorcine zona pellucida (pZP)en_ZA
dc.subjectZona pellucida (ZP)en_ZA
dc.subjectHorse (Equus caballus)en_ZA
dc.subjectOvarian functionen_ZA
dc.subjectAnoestrusen_ZA
dc.subjectOvaryen_ZA
dc.subjectContraceptionen_ZA
dc.titleSerum anti-Müllerian hormone dynamics in mares following immunocontraception with anti-zona pellucida or -GnRH vaccinesen_ZA
dc.typePostprint Articleen_ZA

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