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Isolation of the toxin responsible for gousiekte, a plant-induced cardiomyopathy of ruminants in southern Africa

dc.contributor.authorFourie, Niel
dc.contributor.authorErasmus, G.L.
dc.contributor.authorSchultz, R.A. (Rowena Anitra)
dc.contributor.editorVerwoerd, Daniel Wynand
dc.contributor.upauthorProzesky, Leon
dc.date.accessioned2013-09-12T08:41:28Z
dc.date.available2013-09-12T08:41:28Z
dc.date.created2013
dc.date.issued1995
dc.descriptionThe articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.en
dc.description.abstractGousiekte was induced in sheep and goats by the oral and intravenous (i/v) administration of methanolic and ethanolic precipitates of aqueous extracts of Pavetta harborii. Further purification of the toxic principle was carried out by dialysis and ion-exchange chromatography. The toxin was eluted from the cation-exchange resin with 1 mol/l of ammonium acetate and finally purified on Sephadex G-10 and silica gel. Spots on thin-layer chromatographic plates (TLC) were visualized with ninhydrin. Gousiekte was induced with the pure toxin after i/v administration in goats. The yield of pure toxin was about 10 mg/kg of dried leaves. A compound, indistinguishable from the above on TLC, was also isolated from the gousiekte-inducing plants Pavetta schumanniana, Fadogia homblei and Pachystigma pygmaeum.en
dc.description.librarianmn2013
dc.identifier.citationFourie, N, Erasmus, GL, Schultz, RA & Prozesky, L 1995, 'Isolation of the toxin responsible for gousiekte, a plant-induced cardiomyopathy of ruminants in southern Africa’. Onderstepoort Journal of Veterinary Research, vol. 62, no. 2, pp. 77-87.en
dc.identifier.issn0330-2465
dc.identifier.urihttp://hdl.handle.net/2263/31699
dc.language.isoenen
dc.publisherPublished by the Agricultural Research Council, Onderstepoort Veterinary Instituteen
dc.rights© ARC-Onderstepoort (original). © University of Pretoria. Dept of Library Services (digital).en
dc.subjectVeterinary medicineen
dc.subjectGousiekteen
dc.subjectCardiomyopathyen
dc.subjectCardiac failureen
dc.subjectPlant poisoningen
dc.subjectCardiotoxinen
dc.subject.lcshVeterinary medicine -- South Africa
dc.titleIsolation of the toxin responsible for gousiekte, a plant-induced cardiomyopathy of ruminants in southern Africaen
dc.typeArticleen

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