Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

dc.contributor.authorPark, Thomas J.
dc.contributor.authorReznick, Jane
dc.contributor.authorPeterson, Bethany L.
dc.contributor.authorBlass, Gregory
dc.contributor.authorOmerbasic, Damir
dc.contributor.authorBennett, Nigel Charles
dc.contributor.authorHenning, P.
dc.contributor.authorKuich, J.L.
dc.contributor.authorZasada, Christin
dc.contributor.authorBrowe, Brigitte M.
dc.contributor.authorHamann, Wiebke
dc.contributor.authorApplegate, Daniel T.
dc.contributor.authorRadke, Michael H.
dc.contributor.authorKosten, Tetiana
dc.contributor.authorLutermann, Heike
dc.contributor.authorGavaghan, Victoria
dc.contributor.authorEigenbrod, Ole
dc.contributor.authorBegay, Valerie
dc.contributor.authorAmoroso, Vince G.
dc.contributor.authorGovind, Vidya
dc.contributor.authorMinshall, Richard D.
dc.contributor.authorSmith, Ewan St. J.
dc.contributor.authorLarson, John
dc.contributor.authorGotthardt, Michael
dc.contributor.authorKempa, Stefan
dc.contributor.authorLewin, Gary R.
dc.date.accessioned2017-05-11T09:51:14Z
dc.date.available2017-05-11T09:51:14Z
dc.date.issued2017-04
dc.description.abstractThe African naked mole-rats’ (Heterocephalus glaber) social and subterranean lifestyle generates a hypoxic niche. Under experimental conditions naked mole-rats tolerate hours of extreme hypoxia and survive 18 minutes of total oxygen deprivation (anoxia) without apparent injury. During anoxia the naked mole-rat switches to anaerobic metabolism fueled by fructose which is actively accumulated and metabolized to lactate in the brain. Global expression of the GLUT5 fructose transporter and high levels of ketohexokinase (KHK) were identified as molecular signatures of fructose metabolism. Fructose-driven glycolytic respiration in naked mole-rat tissues avoids feedback inhibition of glycolysis via phosphofructokinase, supporting viability. The metabolic rewiring of glycolysis can circumvent the normally lethal effects of oxygen-deprivation a mechanism that could be harnessed to minimize hypoxic damage in human disease.en_ZA
dc.description.departmentZoology and Entomologyen_ZA
dc.description.librarianhb2017en_ZA
dc.description.urihttp://www.sciencemag.orgen_ZA
dc.identifier.citationPark, TJ, Reznick, J, Peterson, BL, Blass, G, Omerbasic, D, Bennett, NC et al, 2017, 'Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat', Science, vol. 356, no. 6335, pp. 307-311.en_ZA
dc.identifier.issn0036-8075 (print)
dc.identifier.issn1095-9203 (online)
dc.identifier.other10.1126/science.aab3896
dc.identifier.urihttp://hdl.handle.net/2263/60326
dc.language.isoenen_ZA
dc.publisherAmerican Association for the Advancement of Scienceen_ZA
dc.rights© 2017 American Association for the Advancement of Science. All Rights Reserved.en_ZA
dc.subjectAnoxiaen_ZA
dc.subjectOxygen deprivationen_ZA
dc.subjectFructose-driven glycolysisen_ZA
dc.subjectNaked mole-rat (Heterocephalus glaber)en_ZA
dc.titleFructose-driven glycolysis supports anoxia resistance in the naked mole-raten_ZA
dc.typePostprint Articleen_ZA

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