Comparative evaluation of the pathogenicity of Mycoplasma gallinaceum in chickens

dc.contributor.authorAdeyemi, Modupeore
dc.contributor.authorBwala, Dauda Garba
dc.contributor.authorAbolnik, Celia
dc.date.accessioned2018-06-11T11:06:54Z
dc.date.available2018-06-11T11:06:54Z
dc.date.issued2018
dc.description.abstractMycoplasma gallinaceum is not among the most pathogenic mycoplasmas affecting poultry, but its continuous reisolation from flocks in South Africa displaying typical signs of mycoplasmosis prompted us to revisit its role in respiratory disease. Specific-pathogen-free white leghorn chickens were co-challenged with either M. gallinaceum (MGC) and QX-like infectious bronchitis virus (IBV), or the more virulent Mycoplasm gallisepticum (MG) and IBV. No clinical signs were observed apart from sneezing in chickens challenged with IBV, MGCþIBV, and MGþIBV. On postmortem examination, one bird each in the MGC þ IBV and IBV groups developed peritonitis or airsacculitis, respectively. In the tracheas, the MGþ IBV group showed the most severe ciliary damage with a mean ciliostatic score of 32.40 compared to scores of 26.83 and 20.4 for the MGC þ IBV and IBV groups, respectively. Corresponding tracheal lesions were recorded. Quantitation of the challenge pathogens by quantitative realtime PCR and real-time reverse transcriptase–PCR determined that MGC was shed in much higher titers from the trachea than MG, when co-infected with IBV. Interestingly, the presence of both MG and MGC appeared to enhance IBV replication in the tracheas of infected chickens, whereas the presence of IBV suppressed MG and MGC proliferation in the trachea. In general, the nonpathogenicity of M. gallinaceum in chickens was confirmed, but it was able to aggravate respiratory disease and pathogen proliferation with virulent QX-like IBV.en_ZA
dc.description.departmentProduction Animal Studiesen_ZA
dc.description.librarianam2018en_ZA
dc.description.sponsorshipCelia Abolnik’s South African National Research Foundation grant for rated scientists. Modupeore Adeyemi was supported by a University of Pretoria postdoctoral scholarship, and Dauda G. Bwala was supported by a University of Pretoria PhD scholarship.en_ZA
dc.description.urihttp://www.aaapjournals.info/loi/avdien_ZA
dc.identifier.citationAdeyemi, M., Bwala, D.G. & Abolnik, C. 2018, 'Comparative evaluation of the pathogenicity of Mycoplasma gallinaceum in chickens', Avian Deseases, vol. 62, no. 1, pp. 50-56.en_ZA
dc.identifier.issn0005-2086 (print)
dc.identifier.issn1938-4351 (online)
dc.identifier.other10.1637/11743-081717-Reg.1
dc.identifier.urihttp://hdl.handle.net/2263/65114
dc.language.isoenen_ZA
dc.publisherAmerican Association of Avian Pathologistsen_ZA
dc.rights© 2018 American Association of Avian Pathologistsen_ZA
dc.subjectChickensen_ZA
dc.subjectPathogenicityen_ZA
dc.subjectVirusen_ZA
dc.subjectDiseaseen_ZA
dc.subjectPoultryen_ZA
dc.subjectChallengesen_ZA
dc.subjectProtectionen_ZA
dc.subjectInfectious bronchitis virus (IBV)en_ZA
dc.subjectMycoplasma gallinaceum (MGC)en_ZA
dc.subjectMycoplasma gallisepticum (MG)en_ZA
dc.titleComparative evaluation of the pathogenicity of Mycoplasma gallinaceum in chickensen_ZA
dc.typeArticleen_ZA

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