CRISPR-Cas : revolutionising genome engineering
| dc.contributor.author | Nicholson, S.A. | |
| dc.contributor.author | Pepper, Michael Sean | |
| dc.contributor.email | michael.pepper@up.ac.za | en_ZA |
| dc.date.accessioned | 2016-10-24T08:11:46Z | |
| dc.date.available | 2016-10-24T08:11:46Z | |
| dc.date.issued | 2016-09 | |
| dc.description.abstract | The ability to permanently alter or repair the human genome has been the subject of a number of science fiction films, but with the recent advent of several customisable sequence-specific endonuclease technologies, genome engineering looks set to become a clinical reality in the near future. This article discusses recent advancements in the technology called ‘clustered regularly interspaced palindromic repeat (CRISPR)-associated genes’ (CRISPR-Cas), the potential of CRISPR-Cas to revolutionise molecular medicine, and the ethical and regulatory hurdles facing its application. | en_ZA |
| dc.description.department | Immunology | en_ZA |
| dc.description.librarian | am2016 | en_ZA |
| dc.description.sponsorship | South African Medical Research Council University Flagship and Extramural Unit awards. | en_ZA |
| dc.description.uri | http://www.samj.org.za | en_ZA |
| dc.identifier.citation | Nicholson, SA & Pepper, MS 2016, 'CRISPR-Cas : revolutionising genome engineering', South African Medical Journal, vol. 106, no. 9, pp. 870-871. | en_ZA |
| dc.identifier.issn | 0256-9574 (print) | |
| dc.identifier.issn | 2078-5135 (online) | |
| dc.identifier.other | 10.7196/SAMJ.2016.v106i9.11061 | |
| dc.identifier.uri | http://hdl.handle.net/2263/57422 | |
| dc.language.iso | en | en_ZA |
| dc.publisher | Health and Medical Publishing Group | en_ZA |
| dc.rights | © 2016 Health & Medical Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial Works License (CC BY-NC 3.0). | en_ZA |
| dc.subject | CRISPR-Cas | en_ZA |
| dc.subject | Human genome | en_ZA |
| dc.subject | Science fiction films | en_ZA |
| dc.subject | Engineering | en_ZA |
| dc.title | CRISPR-Cas : revolutionising genome engineering | en_ZA |
| dc.type | Article | en_ZA |