Attributable fraction of influenza virus detection to mild and severe respiratory illnesses in HIV-Infected and HIV-uninfected patients, South Africa, 2012–2016

dc.contributor.authorTempia, Stefano
dc.contributor.authorWalaza, Sibongile
dc.contributor.authorMoyes, Jocelyn
dc.contributor.authorCohen, Adam L.
dc.contributor.authorVon Mollendorf, Claire
dc.contributor.authorMcMorrow, Meredith L.
dc.contributor.authorTreurnicht, Florette K.
dc.contributor.authorVenter, Marietjie
dc.contributor.authorPretorius, Marthi Andréa
dc.contributor.authorHellferscee, Orienka
dc.contributor.authorWolter, Nicole
dc.contributor.authorVon Gottberg, Anne
dc.contributor.authorNguweneza, Athermon
dc.contributor.authorMcAnerney, Johanna M.
dc.contributor.authorDawood, Halima
dc.contributor.authorVariava, Ebrahim
dc.contributor.authorMadhi, Shabir A.
dc.contributor.authorCohen, Cheryl
dc.date.accessioned2017-07-27T09:49:54Z
dc.date.available2017-07-27T09:49:54Z
dc.date.issued2017-07
dc.description.abstractThe attributable fraction (AF) of influenza virus detection to illness has not been described for patients in different age groups or with different HIV infection statuses. We compared the age group–specific prevalence of influenza virus infection among patients with influenza-like illness (ILI) or severe acute or chronic respiratory illness (SARI and SCRI, respectively) with that among controls, stratified by HIV serostatus. The overall AF for influenza virus detection to illness was 92.6% for ILI, 87.4% for SARI, and 86.2% for SCRI. Among HIV-uninfected patients, the AF for all syndromes was highest among persons <1 and >65 years of age and lowest among persons 25–44 years of age; this trend was not observed among HIV-infected patients. Overall, influenza viruses when detected in patients with ILI, SARI, or SCRI are likely attributable to illness. This finding is particularly likely among children and the elderly irrespective of HIV serostatus and among HIV-infected persons irrespective of age.en_ZA
dc.description.departmentMedical Virologyen_ZA
dc.description.librarianam2017en_ZA
dc.description.sponsorshipThe National Institute for Communicable Diseases of the National Health Laboratory Service and the Centers for Disease Control and Prevention (cooperative agreement no. 5U51IP000155).en_ZA
dc.description.urihttp://wwwnc.cdc.gov/eiden_ZA
dc.identifier.citationTempia, S, Walaza, S, Moyes, J, Cohen, AL, Von Mollendorf, C, McMorrow, ML, Treurnicht, FK, Venter, M, Pretorius, M, Hellferscee, O, Wolter, N, Von Gottberg, A, Nguweneza, A, McAnerney, JM, Dawood, H, Variava, E, Madhi, SA & Cohen, C 2017, 'Attributable fraction of influenza virus detection to mild and severe respiratory illnesses in HIV-Infected and HIV-uninfected patients, South Africa, 2012–2016', Emerging Infectious Diseases, vol. 23, no. 7, pp. 1124-1132.en_ZA
dc.identifier.issn1080-6040 (print)
dc.identifier.issn1080-6059 (online)
dc.identifier.other10.3201/eid2307.161959
dc.identifier.urihttp://hdl.handle.net/2263/61473
dc.language.isoenen_ZA
dc.publisherCenters for Disease Control and Preventionen_ZA
dc.rights© 2017, Centers for Disease Control and Prevention (CDC). All rights reserved.en_ZA
dc.subjectHIV infectionen_ZA
dc.subjectAgeen_ZA
dc.subjectPatientsen_ZA
dc.subjectHuman immunodeficiency virus (HIV)en_ZA
dc.subjectAttributable fraction (AF)en_ZA
dc.subjectSevere acute respiratory illness (SARI)en_ZA
dc.subjectSevere chronic respiratory illness (SCRI)en_ZA
dc.subjectInfluenza-like illness (ILI)en_ZA
dc.titleAttributable fraction of influenza virus detection to mild and severe respiratory illnesses in HIV-Infected and HIV-uninfected patients, South Africa, 2012–2016en_ZA
dc.typeArticleen_ZA

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