Strain 19 Brucella vaccine. II. The preparation of freeze-dried live vaccine
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Date
Authors
Van Drimmelen, G.C.
Journal Title
Journal ISSN
Volume Title
Publisher
Published by The Government Printer, Pretoria
Abstract
A freeze-dried Brucella vaccine has been developed which can be issued with all the usual guarantees, e.g. 60 x 10⁹ viable organisms per dose viable for an extended period. This vaccine has been prepared in concentrated form which makes it possible to reconstitute the contents of one ampoule into a number of doses. Such a vaccine is eminently suitable for use in Southern Africa especially in the more remote areas. Concentration by means of carboxy-methyl-cellulose of the organisms grown in aerated liquid culture increased the dosage per ampoule and the survival rate after freeze-drying and during storage.
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Keywords
Veterinary medicine
Sustainable Development Goals
Citation
Van Drimmelen, GC 1956, 'Strain 19 brucella vaccine. II. The preparation of freeze-dried live vaccine', Onderstepoort Journal of Veterinary Research, vol. 27, no. 2, pp. 215-225.