Differences in fibrin fiber diameters in healthy individuals and thromboembolic ischemic stroke patients

dc.contributor.authorPretorius, Etheresia
dc.contributor.authorSteyn, Helena C.
dc.contributor.authorEngelbrecht, Mia
dc.contributor.authorSwanepoel, A.C. (Albe Carina)
dc.contributor.authorOberholzer, Hester Magdalena
dc.contributor.emailalbe.swanepoel@up.ac.zaen_ZA
dc.date.accessioned2016-11-30T07:27:02Z
dc.date.available2016-11-30T07:27:02Z
dc.date.issued2011-12
dc.description.abstractCerebrovascular disease is one of the leading causes of death and the cause of long-term adult disability. An important characteristic of thromboembolic ischemic stroke is a prothrombotic or hypercoagulable state and altered fibrin clot structure, whereas a resistance to fibrinolysis is also present. An expansive fibrin network is created when adding thrombin, and in stroke, the network appears thickened, netted and matted, compared with that of healthy individuals. Although this is clearly visible in micrographs of patients, there is a need to quantify the changes. The current study, therefore, investigates fibrin fiber diameters in stroke patients and compares it to healthy individuals. The fiber diameters were measured in nanometres, with University of Texas Health Science Center at San Antonio (UTHSCSA) Image Tool. A total of 100 measurements were done for each of the 12 patients in the healthy control group, and the same number of measurements was done for 12 stroke patients. These measurements were statistically analysed with NCSS 2007, using a significance level of 0.05. Normality was assessed with the Shapiro-Wilk W test and the thickest and thinnest fiber of each individual in the two groups was quantified and differences between groups were assessed with the Student's t-test. Results showed that there is a statistical difference in fibrin fiber thickness during thromboembolic ischemic stroke. We conclude that the changed coagulation and hemostasis, typically associated with stroke, causes a statistically relevant change in fibrin thickness, and that this netted and matted network is more resistant to lyses.en_ZA
dc.description.departmentAnatomyen_ZA
dc.description.departmentPhysiologyen_ZA
dc.description.librarianhb2016en_ZA
dc.description.urihttp://journals.lww.com/bloodcoagulationen_ZA
dc.identifier.citationPretorius, E, Taute, H, Engelbrecht, M, Swanepoel, AC & Oberholzer, HM 2011, 'Differences in fibrin fiber diameters in healthy individuals and thromboembolic ischemic stroke patients', Blood Coagulation and Fibrinolysis, vol. 22, no. 8, pp. 696-700.en_ZA
dc.identifier.issn1473-5733 (online)
dc.identifier.other0957-5235 (print)
dc.identifier.other10.1097/MBC.0b013e32834bdb32
dc.identifier.urihttp://hdl.handle.net/2263/58320
dc.language.isoenen_ZA
dc.publisherLippincott Williams and Wilkinsen_ZA
dc.rights© 2011 Wolters Kluwer Health / Lippincott Williams & Wilkins. This is a non-final version of an article published in final form in Blood Coagulation and Fibrinolysis, vol. 22, no. 8, pp. 696-700, 2011. doi : 10.1097/MBC.0b013e32834bdb32.en_ZA
dc.subjectFiber diametersen_ZA
dc.subjectFibrin networksen_ZA
dc.subjectTromboembolic strokeen_ZA
dc.titleDifferences in fibrin fiber diameters in healthy individuals and thromboembolic ischemic stroke patientsen_ZA
dc.typePostprint Articleen_ZA

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