Ethnobotanical survey and anti-candidal activity of plant species used for oral candidiasis

dc.contributor.authorTlaamela, Dikonketso
dc.contributor.authorMahlo, Salome M.
dc.contributor.authorMcGaw, Lyndy Joy
dc.date.accessioned2024-10-30T12:00:29Z
dc.date.available2024-10-30T12:00:29Z
dc.date.issued2024-07
dc.descriptionDATA AVAILABILITY : The data used to support the findings of this study may be released upon application to the corresponding author, S.M.en_US
dc.description.abstractBACKGROUND : Oral candidiasis is caused by Candida albicans, which is most prevalent in immunocompromised patients. AIM : The study aimed to investigate the antifungal activity of plant species used for oral candidiasis against C. albicans. SETTING : The study was conducted in Aganang Local Municipality, Capricorn District, Limpopo province, South Africa. METHODS : A survey was conducted using a semi-structured questionnaire supplemented with guided field walks with traditional health practitioners to gather information on medicinal plants used to treat oral candidiasis. Nine plant species (Artemisia afra Jacq. ex Willd., Blepharis subvolubilis subsp. subvolubilis C.B. Clarke, Enicostemma axillare [Lam.], Helichrysum caespititium [DC.] Harv., Solanum incanum L., Waltheria indica L., Ximenia caffra Sond. var. caffra, Ximenia caffra Sond. var. natalensis and Ziziphus mucronata Willd.) were investigated for antifungal activity. The plant material were extracted with solvents of varying polarities: acetone, dichloromethane, ethyl acetate, ethanol, hexane, methanol, and water. The Micro-dilution and bioautography assays were used to determine the antifungal activity of the plant extracts. RESULTS : Leaf extracts of A. afra and S. incanum were more active against C. albicans with MIC values of 0.02 mg/mL. Bioautography assay demonstrated active compounds in S. incanum, W. indica and X. caffra var. caffra extracts developed in Benzene: Ethanol: Ammonia hydroxide (BEA). CONCLUSION : An ethnobotanical survey is a worthy starting point in selecting potential plant species for ethnopharmacological studies. CONTRIBUTION : The effectiveness of oral administrations of the medicinal plants was confirmed by the excellent antifungal activity of the aqueous extracts.en_US
dc.description.departmentParaclinical Sciencesen_US
dc.description.librarianhj2024en_US
dc.description.sdgSDG-03:Good heatlh and well-beingen_US
dc.description.sponsorshipThe National Research Foundation (NRF).en_US
dc.description.urihttp://www.jomped.org/en_US
dc.identifier.citationTlaamela, D., Mahlo, S. & McGaw, L., 2024, ‘Ethnobotanical survey and anti-candidal activity of plant species used for oral candidiasis’, Journal of Medicinal Plants for Economic Development 8(1), a220. https://doi.org/10.4102/jomped.v8i1.220.en_US
dc.identifier.issn2519-559X (print)
dc.identifier.issn2616-4809 (online)
dc.identifier.other10.4102/jomped.v8i1.220
dc.identifier.urihttp://hdl.handle.net/2263/98848
dc.language.isoenen_US
dc.publisherAOSISen_US
dc.rights© 2024. The Authors. Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.en_US
dc.subjectMedicinal plantsen_US
dc.subjectCandidiasisen_US
dc.subjectEthnobotanical surveyen_US
dc.subjectAntifungal activityen_US
dc.subjectMinimum inhibitory concentration (MIC)en_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.titleEthnobotanical survey and anti-candidal activity of plant species used for oral candidiasisen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Tlaamela_Ethnobotanical_2024.pdf
Size:
1.45 MB
Format:
Adobe Portable Document Format
Description:
Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: